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| Slitrk基因家族的研究进展 | |
| 引用本文： | 靳雁斌,范文红,范明. Slitrk基因家族的研究进展[J]. 国际病理科学与临床杂志, 2006, 26(2): 19-161 |
| 作者姓名： | 靳雁斌 范文红 范明 |
| 作者单位： | 军事医学科学院基础医学研究所脑保护与可塑性研究室,北京,100850 |
| 摘 要： | Slitrk基因家族是一类调节神经突生长的结构相关的跨膜蛋白，有6个成员。Slitrk蛋白有氨基末端的亮氨酸重复序列(LRRs)和羧基末端的酪氨酸残基2个保守结构域，它们分别与轴突导向因子Slit和神经营养因子受体TrkA的相应结构同源，且功能有相近之处。人与鼠Slitrk家族各成员的氨基酸序列高度同源。除Slitrk6外Slitrk其他成员的表达都局限于神经组织，Slitrk1，Slitrk2的分布具有互补性。Slitrk基因还在多种神经上皮肿瘤中有不同程度的表达。 |
| 关 键 词： | Slitrk Slit TrkA LRR 酪氨酸残基 |
| 文章编号： | 1673-2588(2006)02-0159-03 |
| 收稿时间： | 2005-11-02 |
| 修稿时间： | 2005-11-02 |
Progression of Slitrk genes |
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| JIN Yan-Bin,FAN Wen-Hong,FAN Ming. Progression of Slitrk genes[J]. Journal of International Pathology and Clinical Medicine, 2006, 26(2): 19-161 | |
| Authors: | JIN Yan-Bin FAN Wen-Hong FAN Ming |
| Affiliation: | Department of Brain Protection and Neural Plasticity, Institute of Basic Medical Sciences,Academy of Military Medical Sciences, Beijing 100850, China |
| Abstract: | The Slitrk family consists of six structurally related transmembrane proteins which control the neurite outgrowth.The Slitrk proteins contain 2 conserved domains: 2 leucine-rich repeat(LRR) domains in the amino-terminal and tyrosine residue in the carboxy-terminal,which have significant homology and similar function to Slit and TrkA respectively.Comparison of the amino acid sequences reveals strong homology between Slitrk members in mouse and humans.The expressions of all Slitrks except Slitrk6 are highly restricted to neural tissues.The distribution patterns of Slitrk1 and Slitrk2 are almost complementary.In addition,the Slitrk genes are differentially expressed in various types of neuroepithelial tumours. |
| Keywords: | Slitrk Slit TrkA LRR tyrosine residue |
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