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| Caveolin-1和E-cadherin在肾细胞癌中的表达及其意义 | |
| 引用本文： | WANG Li,罗金芳,GUI Lu,张友元. Caveolin-1和E-cadherin在肾细胞癌中的表达及其意义[J]. 临床泌尿外科杂志, 2008, 23(4) |
| 作者姓名： | WANG Li 罗金芳 GUI Lu 张友元 |
| 作者单位： | 复旦大学附属金山医院病理科,上海,200540;复旦大学附属金山医院病理科,上海,200540;复旦大学附属金山医院病理科,上海,200540;复旦大学附属金山医院病理科,上海,200540 |
| 摘 要： | 目的:探讨Caveolin-1、E-cadherin在肾细胞癌中的表达及其临床意义.方法:采用免疫组织化学EnVision法检测41例肾细胞癌切除标本中Caveolin-1和E-cadherin的表达,并分析表达情况与肿瘤的生物学行为的关系.结果:Caveolin-1在肾细胞癌中的表达阳性率为41.5%,与肿瘤分期、Fuhrman分级及患者年龄呈正相关(P<0.05);E-cadherin表达阳性率为24.4%,低于癌旁肾组织(50%),E-cadherin表达与肿瘤细胞核分级相关(P<0.05),与其他临床病理参数之间无相关性.Caveolin-1和E-cadherin两者之间表达无相关性.结论:Caveolin-1过表达及E-cadherin的异常表达,可能在肾细胞癌的生长、分化中发挥重要作用. |
| 关 键 词： | 肾肿瘤 细胞癌 微囊蛋白 肿瘤标志物 |
Expression of Caveolin-1 and E-cadherin in renal cell carcinoma |
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| WANG Li,LUO Jingfang,GUI Lu,ZHANG Youyuan. Expression of Caveolin-1 and E-cadherin in renal cell carcinoma[J]. Journal of Clinical Urology, 2008, 23(4) | |
| Authors: | WANG Li LUO Jingfang GUI Lu ZHANG Youyuan |
| Affiliation: | 1 Department of Pathology;Jinshan Hospital;Fudan University;Shanghai;200540;China |
| Abstract: | Objective:To evaluate expression of Caveolin-1 and E-cadherin in renal cell carcinoma and to investigate their associations with clinicopathological parameters.Methods:Expression of Caveolin-1 and E-cadherin were evaluated by immunohistochemistry in 41paraffin embedded renal cell carcinoma specimens.Associations between their expressions and pathological stage,tumor grade,size of tumor were analyzed.Results:Of 41 tumors 17(41.5%) were considered Caveolin-1 positive.Significant associations between Caveolin-... |
| Keywords: | Renal tumor Cell carcinoma Caveolin Tumor marker |
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