| 中老年T2DM人群CKD的演变规律 |
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| 引用本文： | 陈振鸿,窦京涛,陆菊明,母义明,吕朝晖,巴建明,孙新华.中老年T2DM人群CKD的演变规律[J].军医进修学院学报,2009,30(3):267-269. |
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| 作者姓名： | 陈振鸿 窦京涛 陆菊明 母义明 吕朝晖 巴建明 孙新华 |
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| 作者单位： | 1. 解放军总医院,内分泌科,北京,100853
2. 北京朝阳医院西区,药剂科,北京,100043 |
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| 摘 要： | 目的：探讨中老年2型糖尿病（T2DM）人群慢性肾脏疾病（CKD）的发展变化及预后。方法：我院“两次入院,时间间隔0.5～5.5年”的CKD患者112例,统计不同血肌酐和尿蛋白组合的脑梗塞、ESRD和透析治疗等事件的5年累积率和发生率,以及各组5年后的eGFR水平和变化值,探讨CKD的演变规律。结果：四组的eGFR和SCr的变化速度由小到大依次为：“肌酐正常-尿蛋白正常组”〈“肌酐正常-蛋白尿组”〈“肌酐升高-尿蛋白正常组”〈“肌酐升高-蛋白尿组”,且“肌酐升高-蛋白尿组”的脑梗塞、ESRD和透析发生率明显高于其他组。影响血肌酐进展速度的逐步回归分析可见ACR、SCr和CA15-3对血肌酐进展速度有明显的线性影响,P〈0.01。结论：“肌酐升高-蛋白尿组”CKD的进展最快,预后最差;微量蛋白尿、SCr和CA15-3是CKD危险因素。
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| 关 键 词： | 肾脏功能不全 2型糖尿病 预后 |
Regularity for development of CKD in middle-aged and old patients with type 2 diabetes |
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| CHEN Zhen-hong,DOU Jing-tao,LU Ju-ming,MU Yi-ming,LV Zhao-hui,BA Jian-ming,SUN Xin-hua.Regularity for development of CKD in middle-aged and old patients with type 2 diabetes[J].Academic Journal of Pla Postgraduate Medical School,2009,30(3):267-269. |
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| Authors: | CHEN Zhen-hong DOU Jing-tao LU Ju-ming MU Yi-ming LV Zhao-hui BA Jian-ming SUN Xin-hua |
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| Institution: | 1.Department of Endocrinology;Chinese PLA General Hospital;Beijing 100853;China;2.Department of Pharmacy;Beijing chaoyang Hospital;Beijing 100043;China |
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| Abstract: | Objective:To evaluate the risk factors for development of chronic kidney disease(CKD) in middle-aged and old patients with type 2 diabetes and to explore the prognosis and development rule of CKD.Methods:One hundred and twelve patients with type 2 diabetes over the age of 50 years,who were admitted twice to the Chinese PLA General Hospital between 2000 and 2008,were studied.The patients were divided into 4 groups according to their serum creatinine(normal,high) and urine protein(normal,albuminuria) levels.S... |
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| Keywords: | chronic kidney disease diabetes mellitus type 2 prognosis |
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