新诊断2型糖尿病慢性并发症的调查分析及中医证型的研究

目的:调查新诊断2型糖尿病(T2DM)患者的临床特征及慢性并发症情况,探讨新诊断T2DM的中医证型与慢性并发症的关系.方法:根据本研究的病例纳入及排除标准,按照统一制定的调查表对成都中医药大学附属医院2008年12月～2010年12月内分泌科的门诊及住院新诊断T2DM患者,采集其临床及中医辨证分型资料,按照有无并发症分...

Epidemiology of Chronic Diabetic Complications and Research of Symptoms of Traditional Chinese Medicine among Newly-diagnosed Type 2 Diabetes

Objective:To investigate clinical characteristics and the chronic complications status of newly-diagnosed type 2 diabetes mellitus,and discuss the relationship between the Chinese medicine patterns and the chronic complications of newly-diagnosed type 2 diabetes mellitus.Method According to the research’s case integrated and eliminated standards,in terms of unitive survey form to investigate the Chengdu University of Traditional Chinese Medicine affiliated hospital from October,2008 to October,2010 Department of Endocrinology outpatient and inpatient of newly-diagnosed type 2 diabetes mellitus,gather their clinical and the Chinese syndrome differentiation materials,group whether there is complications,to do the related statistics analysis,comparing differences between two groups.Result In 188 newly-diagnosed type 2 diabetes mellitus patients which are integrated,111 patients exist at least one kind of chronic complications,the morbidity reaches high as 59.04%.In the chronic complications group,the morbidity of combination with lipid metabolic disorder is highest,reaching as 61.3%.The Chinese pattern of syndrome of newly-diagnosed type 2 diabetes mellitus patients is still mainly qi and yin deficiency,deficient syndrome ratio obviously is higher than sufficient syndrome,the frequency of the qi deficient syndrome is above the yin deficient syndrome,the frequency of excess heat syndrome is less than 20%,deficient syndrome between two groups have no significant difference,in sufficient syndrome,both P value of phlegm-damp syndromeand blood stasis syndrome is smaller than 0.01,have the significant difference;Diabetic great vessel pathological changes have positive correlation with qi deficiency syndrome,yin deficiency syndrome,the blood stasis syndrome(r=0.102、0.107、0.118,P<0.05),phlegm-damp syndrome significantly(r =0.166,P<0.01);Diabetes microvascular pathological changes have positive correlation with qi deficiency syndrome(r=0.113,P<0.05),the blood stasis syndrome significantly(r=0.196,P<0.01).Conclusions The the morbidity of newly-diagnosed type 2 diabetes mellitus chronic complications is high,awareness rate is low."The sugar toxin" and "the lipid toxin" possibly is the important factor which accelerate occurrence of chronic complications,the prevention should pay great attention to control the multiple risk factors.Characteristics of diabetic chronic complications is "asthenia in origin and excess in superficiality"."Deficiency、blood stasis" are throughout diabetes and its chronic complications."Qi and yin deficiency,hlegm-damp and blood stasis blocking venation" possibly is the common pathologic foundation causing the diabetic chronic complications.