|
|||||
|
|
| NEDD9在子宫内膜样腺癌中的表达及意义 | |
| 引用本文： | 李爱琳,姚雷,邓博雅,柏兴华,姜彦多,李光. NEDD9在子宫内膜样腺癌中的表达及意义[J]. 解剖科学进展, 2012, 18(5): 405-408 |
| 作者姓名： | 李爱琳 姚雷 邓博雅 柏兴华 姜彦多 李光 |
| 作者单位： | 1. 中国医科大学附属第一医院放疗科,辽宁沈阳,110001 2. 中国医科大学附属第一医院妇科,辽宁沈阳,110001 3. 中国人民解放军第二零二医院病理科,辽宁沈阳,110003 |
| 基金项目： | 辽宁省科学技术计划项目 |
| 摘 要： | 目的 探讨NEDD9(neural precursor cell expressed developmentally down-regulated9)在子宫内膜样腺癌中的表达及意义。方法 应用免疫组化方法检测NEDD9在50例子宫内膜样腺癌和30例子宫内膜单纯性增生组织中的表达,并检测雌激素受体(ER)、孕激素受体(PR)在子宫内膜样腺癌的表达。结果 NEDD9在子宫内膜样腺癌中的表达高于在子宫内膜单纯性增生组织中的表达(p=0.226);在子宫内膜样腺癌中,NEDD9的高表达与肌层浸润≥1/2、FIGO分期III期和ER阴性表达相关(p=0.012,p=0.041及p=0.039)。结论 NEDD9促进子宫内膜样腺癌的侵袭,并与其ER表达状态负相关。 |
| 关 键 词： | NEDD9基因 子宫内膜样腺癌 雌激素受体 孕激素受体 人 |
Expression of NEDD9 in human endometrial carcinomas |
|
| LI Ai-lin , YAO Lei , DENG Bo-ya , BAI Xing-hua , JIANG Yan-duo , LI Guang. Expression of NEDD9 in human endometrial carcinomas[J]. Progress of Anatomical Sciences, 2012, 18(5): 405-408 | |
| Authors: | LI Ai-lin YAO Lei DENG Bo-ya BAI Xing-hua JIANG Yan-duo LI Guang |
| Affiliation: | 1. Department of Radiotheropy, 2. Department of Gynecology, The First Affiliated Hospital, China Medical University, Shenyang 110001, China; 3. Department of Pathology, No 202 Hospital of People Liberation Army of China, Shenyang 110003, China) |
| Abstract: | Objective The aim of this study was to investigate the expression of neural precursor cell expressed developmentally down-regulated 9（NEDD9） gene in endometrial carcinoma and benign endometrial hyperplasia, and assess their correlations with clinicopathological parameters, estrogen receptor （ ER ） and progesterone receptor （ PR ） . Methods The expressions of ER and PR and NEDD9 in normal proliferative endometrium samples and endometfial carcinoma samples were measured by immunohistochemistry. Results The expression level of NEDD9 in endometrial carcinoma was higher than in normal proliferative endometrium （p=0.226）. In endometrial cancer, increased NEDD9 expression was significantly related to myometrial invasion ≥ 1/2, FIGO III Stage and ER positive expression （P=0.012, P=0.041 and P=0.039 respectively）. Conclusion NEDD9 may he involved in the endometrial carcinoma progression and negatively correlated to ER expression. |
| Keywords: | neural precursor cell expressed developmentally down-regulated 9 endometrial carcinoma estrogen receptor progesterone receptor human |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |