| 口腔鳞癌卡铂,平阳霉素,氨甲喋呤术前诱导化疗的临床研究 |
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| 引用本文： | 郅克谦,李亚军,张密荣,任文豪,荔鹏,李心强.口腔鳞癌卡铂,平阳霉素,氨甲喋呤术前诱导化疗的临床研究[J].陕西肿瘤医学,2010,18(4):685-687. |
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| 作者姓名： | 郅克谦 李亚军 张密荣 任文豪 荔鹏 李心强 |
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| 作者单位： | [1]西安交通大学医学院附属口腔医院口腔颌面外科,陕西西安710004 [2]陕西省米脂县医院口腔科,陕西米脂718100 [3]陕西省泾阳县医院口腔科,陕西泾阳713700 |
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| 基金项目： | 陕西省社发攻关项目（2009K17-03）; 西安市科技计划项目（SF09030-4）; 西安交通大学口腔医院教改项目（2008JX-5 2009JX-10） |
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| 摘 要： | 目的：探讨卡铂,平阳霉素,氨甲喋呤术前诱导化疗对口腔鳞癌的临床效应。方法：45例32-72岁的口腔鳞癌患者,采用卡铂,平阳霉素,氨甲喋呤术前诱导化疗1个周期,化疗后3-5天,对常规检查正常者再进行手术治疗,对其近期疗效进行评价,随访3-5年。结果：诱导化疗后80%的患者肿瘤缩小50%以上,39例手术患者近期疗效评价中,完全缓解1例,部分缓解14例,无效16例;术后3、5年生存率分别为71.2%、66.7%。结论：卡铂,平阳霉素,氨甲喋呤用于口腔鳞癌术前诱导化疗,具有较满意的临床效果,与相应的手术相结合可以提高患者远期生存率。
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| 关 键 词： | 口腔鳞癌 术前诱导化疗 临床研究 |
Induction chemotherapy of combined carboplatin,pingyangmy and methotrexate for oral squamous cell carcinoma |
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| ZHI Ke-qian,LI Ya-jun,ZHANG Mi-rong,REN Wen-hao,LI Peng,LI Xin-qiang.Induction chemotherapy of combined carboplatin,pingyangmy and methotrexate for oral squamous cell carcinoma[J].Shaanxi Oncology Medicine,2010,18(4):685-687. |
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| Authors: | ZHI Ke-qian LI Ya-jun ZHANG Mi-rong REN Wen-hao LI Peng LI Xin-qiang |
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| Institution: | 1.Department of Oral and Maxillofacial Surgery,Stomotological Hospital,Medical School of Xi＇an Jiaotong University,Xi＇an 710004,China;2.Department of Stomatology,Mizhi County Hospital in Shaanxi Province,Mizhi 718100,China;3.Department of Stomatology,Jingyang County Hospital in Shaanxi Province,Jingyang 713700,China.) |
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| Abstract: | Objective：To investigate the clinical effects of combined Carboplatin,Pingyangmy and Methotrexate preoperative induction chemotherapy for oral squamous cell carcinoma.Methods： Forty-five cases of 32-72 year-old patients with oral squamous cell carcinoma were treated with preoperative combined chemotherapy lasted for one course,after a lapse of 3-5 days,surgical operations were performed for patients with normal routine examinations.Short-term curative effects were assessed,and 3,5-year survival rates were followed up.Results： Complete and partial response rate was 80%.One case showed totally relief;partially relief in 14 cases,16 cases invalid,the 3,5-year survival rates after operation were 71.2% and 66.7%,respectively.Conclusion： The combination of Carboplatin,Pingyangmy and Methotrexate induction chemotherapy possesses considerable satisfactory clinical effects,if followed by surgical intervention,it will improve the long-term survival rate. |
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| Keywords: | oral squamous cell carcinoma preoperative inductive chemotherapy clinical study |
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