| 雷公藤内酯醇在大鼠体内的组织分布 |
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| 引用本文： | 黄秀旺,许建华,陈元仲. 雷公藤内酯醇在大鼠体内的组织分布[J]. 中国临床药理学与治疗学, 2008, 13(7): 764-767 |
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| 作者姓名： | 黄秀旺 许建华 陈元仲 |
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| 作者单位： | 1. 福建医科大学药学院临床药理研究所,福州,350004,福建
2. 福建医科大学附属协和医院血液病研究所,福州,350001,福建 |
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| 基金项目： | 福建省重大专项前期研究课题，福建省科技攻关项目 |
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| 摘 要： | 目的：建立雷公藤内酯醇的反相高效液相色谱分析方法,并对其在大鼠的组织分布进行测定。方法：用HPLC紫外检测方法测定大鼠i.v.雷公藤内酯醇后各组织中药物的含量。结果：大鼠i.v.200μg/kg的雷公藤内酯醇后药物在体内分布广泛,以肺、肝、肾中分布较高,各组织的药物含量于给药后5min最高,60min后显著下降。结论：雷公藤内酯醇在大鼠体内分布快且广泛,消除也快,且可穿越血脑屏障和血睾屏障分布到脑和睾丸中。
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| 关 键 词： | 雷公藤内酯醇 高效液相色谱 组织分布 |
Tissue distribution of triptolide in rats |
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| HUANG Xiu-wang,XU Jian-hua,CHEN Yuan-zhong. Tissue distribution of triptolide in rats[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2008, 13(7): 764-767 |
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| Authors: | HUANG Xiu-wang XU Jian-hua CHEN Yuan-zhong |
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| Affiliation: | HUANG Xiu-wang, XU Jian-hua, CHEN Yuan-zhong (1.Institute of Clinical Pharmacology, Department of Pharmacology, Fujian Medical University, Fuzhou 350004, Fujian, China ; 2.Institute of Hematology, Affiliated Union Hospital , Fujian Medical University, Fuzhou 350001, Fujian, China ) |
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| Abstract: | AIM： To establish an HPLC method for the analysis of tissue distribution of triptolide in rats. METHODS： The concentrations of tfiptolide in biological samples were determined by an HPLC meth- od with UV detection. RESULTS： The results of tissue distribution showed that triptolide was distributed widely in rats. The highest levels were found in lung, liver and kidney after i.v. administration （200 ug/kg） of triptolide. The peak levels appeared at 5 min and decreased significantly in 60 min in most tissues. CONCLUSION： Triptolide is widely distributed and rapidly eliminated in main tissues, and it can permeate blood brain barrier and blood testicle barrier. |
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| Keywords: | triptolide HPLC tissue distribution |
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