| 奥沙利铂神经毒性处理及预防研究进展 |
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| 引用本文： | 王莉,王琳,秦叔逵. 奥沙利铂神经毒性处理及预防研究进展[J]. 医学综述, 2006, 12(8): 490-492 |
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| 作者姓名： | 王莉 王琳 秦叔逵 |
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| 作者单位： | 中国人民解放军第八一医院全军肿瘤中心内科,南京,210002 |
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| 摘 要： | 神经毒性是OXA最常发生的剂量限制性毒性,近期研究发现OXA急性毒性的产生可能与一过性的钙依赖的钠通道功能失调有关,这一作用可被Na+通道阻滞剂所阻断,临床发现支持这一观点,这些临床发现指出药学性阻断Na+通道可预防和(或)抑制OXA的神经毒性。本文综述了OXA神经毒性的细胞机制、病理生理及处理预防措施进展。
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| 关 键 词： | 奥沙利铂 神经毒性 预防 神经调节剂 |
| 文章编号： | 1006-2084（2006）08-0490-03 |
| 收稿时间： | 2005-07-17 |
| 修稿时间： | 2006-04-07 |
The Progress in Treatment and Prevention of OXA about its Neurotoxicity |
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| WANG Li,WANG Lin,QIN Shu-kui. The Progress in Treatment and Prevention of OXA about its Neurotoxicity[J]. Medical Recapitulate, 2006, 12(8): 490-492 |
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| Authors: | WANG Li WANG Lin QIN Shu-kui |
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| Affiliation: | The Department of Internal Medicine in Tumor Center, No. 81 Hospital of PLA , Nanfing 210002, China |
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| Abstract: | Neurotoxicity is the most frequent dose-limiting toxicity-of oxaliplatin, Recent data indicates that the acute toxicity of oxaliplatin maybe associated with temple functional disorder of sodium channel depended on calcium, which can be inhibited by sodium channel blocker. Many clinical found can also support this view, which indicates phamnceuticcal inhibition of sodium channel can prevent/inhibite the neurotexicity of oxaliplatin. This article reviews the progress of OXA about its cell mechanism,pathophysiology and methods of treatment and prevention. |
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| Keywords: | Oxaliplatin Ncurotoxicity Prevention Neuroregulator |
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