E-cadherin和nm23-H1的表达及其临床意义在胰腺癌

目的探讨上皮细胞钙黏蛋白（E-cadherin）和转移抑制基因（nm23-H1）表达与胰腺癌侵袭转移的关系。方法应用免疫组织化学技术SP法，检测31例癌组织中E-cadherin和nm23-H1的表达水平。结合肿瘤的侵袭转移能力、分化程度和分期等进行分析。结果31例胰腺癌组织中E-cadherin和nm23-H1的表达强度均低于对照的胰腺组织；E-cadherin和nm23-H1的表达强度与胰腺癌的远处转移能力密切相关；胰腺癌中E-cadherin和nm23-H1的表达具有明显正相关。结论E-cadherin和nm23-H1的表达水平能反映胰腺癌的侵袭转移能力。两种蛋白的表达水平之间呈明显正相关。联合检测两种蛋白在胰腺癌组织中的表达，对临床判断胰腺癌的预后可能有一定的意义。

The expression of E-cadherin and nm23-H1 in pancreatic cancer and its clinical significance

Objective To investigate the expression of E-cadherin and nm23-H1 and their correlation with the invasion and metastasis of pancreatic cancer.Methods Immunohistochemical technique was used to detect the expression of E-cadherin and nm23-H1 in 31 cases of pancreatic cancer,8 normal pancreatic tissues and 7 cases of chronic pancreatitis.Invasion,metastasis and differentiation and staging in pancreatic cancer were analyzed.Results In 31 cases of pancreatic cancer,the expression levels of E-cadherin and nm23-H1 were lower than in the control tissues(P<0.05).The expression intensity of E-cadherin and nm23-H1 was significantly positively correlated with the distant metastasis of pancreatic cancer.In pancreatic cancer,there was a significantly positive correlation between the expression of E-cadherin and nm23-H1.Conclusion The expression of E-cadherin and nm23-H1 can reveal the invasion and metastasis ability of pancreatic cancer.Combined detection of the E-cadherin and nm23-H1 protein expression in pancreatic cancer tissues may play some roles in clinically evaluating the the prognosis of pancreatic cancer.