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Resequencing and association analysis of MIR137 with schizophrenia in a Japanese population |
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| Authors: | Jun Egawa MD PhD Ayako Nunokawa MD PhD Masako Shibuya MD PhD Yuichiro Watanabe MD PhD Naoshi Kaneko MD PhD Hirofumi Igeta MD Toshiyuki Someya MD PhD |
| Institution: | 1. Department of Psychiatry, Niigata University Graduate School of Medical and Dental Sciences, , Niigata, Japan;2. Department of Psychiatry, National Hospital Organization, Saigata National Hospital, , Niigata, Japan;3. Niigata Psychiatric Center, , Niigata, Japan;4. Health Administration Center, Headquarters for Health Administration, Niigata University, , Niigata, Japan;5. Division of Medical Education, Comprehensive Medical Education Center, School of Medicine, Faculty of Medicine, Niigata University, , Niigata, Japan;6. Oojima Hospital, , Niigata, Japan |
| Abstract: | MicroRNA may play a role in the pathophysiology of schizophrenia. A recent meta‐analysis of genome‐wide association studies indicated a significant association between schizophrenia and a common intronic variation in MIR137HG (microRNA 137 host gene) encoding the primary microRNA‐137. To explore additional risk variations for schizophrenia, we resequenced MIR137 and performed an association analysis in 1321 Japanese individuals. By resequencing, we detected four sequence variations in the 5' and 3' flanking regions. There were no significant associations between these variations and schizophrenia. Our resequencing and association analysis of MIR137 failed to find additional risk variations for schizophrenia. |
| Keywords: | MIR137 resequencing schizophrenia single nucleotide variation variable number of tandem repeats |