| Progesterone receptors A and B differentially modulate corticotropin-releasing hormone gene expression through a cAMP regulatory element |
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| 引用本文： | NiX HouY YangR TangX SmithR NicholsonRC. Progesterone receptors A and B differentially modulate corticotropin-releasing hormone gene expression through a cAMP regulatory element[J]. 第二军医大学学报, 2005, 26(4): 435-435 |
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| 作者姓名： | NiX HouY YangR TangX SmithR NicholsonRC |
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| 作者单位： | DepartmentofPhysiology,SecondMilitaryMedicalUniversity,Shanghai200433,China |
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| 摘 要： | ![]()
Corticotrophin-releasing hormone (CRH) plays a major role in mechanisms controlling human pregnancy and parturition. Gene regulation by progesterone may be a key point in the control of placental CRH production. Studies in primary placental ceils show that antagonism of progesterone activity or production by RU486 or trilostane leads to an increase in CRH promoter activity. This effect can be reversed by the addition of progesterone. Overexpression of progesterone receptor A (PRA) or glucocorticoid receptor resulted in a decrease in CRH promoter activity following progesterone treatment, whereas an increase in promoter activity was observed with overexpressed PR-B.
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| 关 键 词： | 黄体酮 激素释放 激素因子 cAMP |
Progesterone receptors A and B differentially modulate corticotropin-releasing hormone gene expression through a cAMP regulatory element |
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| Ni X,Hou Y,Yang R,Tang X,Smith R,Nicholson RC. Progesterone receptors A and B differentially modulate corticotropin-releasing hormone gene expression through a cAMP regulatory element[J]. Former Academic Journal of Second Military Medical University, 2005, 26(4): 435-435 |
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| Authors: | Ni X Hou Y Yang R Tang X Smith R Nicholson RC |
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| Affiliation: | Ni X；Hou Y；Yang R；Tang X；Smith R；Nicholson RC |
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| Abstract: | ![]()
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