| 血小板膜糖蛋白CD41/CD61基因多态性及表达率与脑梗死的关系 |
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| 引用本文： | 李洪波,朱辛明,宋玉国,熊英,王萍. 血小板膜糖蛋白CD41/CD61基因多态性及表达率与脑梗死的关系[J]. 中风与神经疾病杂志, 2011, 28(7) |
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| 作者姓名： | 李洪波 朱辛明 宋玉国 熊英 王萍 |
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| 作者单位： | 北华大学附属医院特需诊疗科,吉林,吉林,132011 |
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| 摘 要： | 目的探讨血小板膜糖蛋白CD41/CD61与脑梗死的关系。方法应用聚合酶链反应-限制性片断长度多态性分析技术(PCR-RFLP)和同步流式细胞术,分别检测CD41/CD61的基因多态性和表达率,并进行脑梗死组和对照组比较,其中脑梗死组115例:男64例,女51例,年龄36~77岁;对照组103例:男59例,女44例,年龄33~79岁。结果 (1)脑梗死组CD41 aa、ab和bb基因分布频率分别为20.0%、38.3%和41.7%,对照组分别为28.2%、48.5%和23.3%;两组间比较bb基因型有统计学意义(P<0.05);脑梗死组b等位基因频率(60.4%)高于对照组(47.6%),P<0.05。(2)CD61基因型均为aa型(未切开型)。(3)脑梗死组CD41/CD61表达率为96.0%±8%,对照组为85.5%±13%,差异有统计学意义(P<0.05)。(4)脑梗死组CD41 bb、aa基因型表达率分别为98.5%±13%、91.3%±8%,差异显著(P<0.05)。结论脑梗死与血小板膜糖蛋白CD41/CD61密切相关,CD41 bb基因影响CD41/CD61表达率;分析CD41基因多态性结合检测CD...
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| 关 键 词： | 血小板膜糖蛋白 脑梗死 基因多态性 流式细胞术 |
Relationship between the gene polymorphisms with expressions of platelet glycoprotein CD41/CD61 and cerebral infarction |
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| LI Hong-bo,ZHU Xin-ming,SONG Yu-guo,et al.. Relationship between the gene polymorphisms with expressions of platelet glycoprotein CD41/CD61 and cerebral infarction[J]. Journal of Apoplexy and Nervous Diseases, 2011, 28(7) |
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| Authors: | LI Hong-bo ZHU Xin-ming SONG Yu-guo et al. |
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| Affiliation: | LI Hong-bo,ZHU Xin-ming,SONG Yu-guo,et al.(Department of Special Diagnosis,The Affiliated Hospital of Beihua University,Jilin 132011,China) |
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| Abstract: | Objective To study the relationship between platelet glycoprotein CD41/CD61 and cerebral infarction(CI).Methods 115 patients with CI cases,with 64 men and 51 women(aged from 36 to 77 years),and 103 normal controls,with 59 men and 44 women(aged from 33 to 79 years) were studied.By the polymerase chain reaction and restriction fragment length polymorphism(PCR-RFLP),the platelet membrane glycoprotein CD41/CD61 gene polymorphism was analyzed.The expression of CD41/CD61 was detected by flow cytometry.Results The... |
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| Keywords: | Gene polymorphism Plateletmembrane glycoprotein Cerebral infaretion Flowcytometry |
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