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| 河南汉族人群eNOS基因VNTR多态性与缺血性脑血管病的关系 | |
| 引用本文： | 李艾帆,许予明,郑红,张晓曼,逄涛. 河南汉族人群eNOS基因VNTR多态性与缺血性脑血管病的关系[J]. 中风与神经疾病杂志, 2011, 28(5) |
| 作者姓名： | 李艾帆 许予明 郑红 张晓曼 逄涛 |
| 作者单位： | 1. 郑州市第一人民医院神经内科,河南郑州,450000 2. 郑州大学第一附属医院神经内科,河南郑州,450052 3. 郑州大学基础医学院细胞生物学与医学遗传学教研室,河南郑州,450052 |
| 摘 要： | 目的 探讨河南汉族人群内皮细胞性一氧化氮合酶(eNOS)基因内含子4可变性重复序列(VN-TR)的多态性与缺血性脑血管病(ICVD)的关系.方法 应用聚合酶链反应(PCR)技术,检测488例缺血性脑血管病患者的基因型,并与对照组比较.结果 缺血性脑血管病组eNOS基因ab基因型的频率(18.4%)明显高于对照组(13.57%),a等位基因的频率(11.5%)也明显高于对照组(7.7%),差异均有显著性(P＜0.05).结论 eNOS基因ab基因型与缺血性脑血管病有相关性,等位基因a可能是缺血性脑血管病的危险因素. |
| 关 键 词： | 一氧化氮合酶 基因多态性 缺血性脑血管病 |
Association between variabe number of tandem repeat polymorphism of endothelial nitric oxide synthase gene and ischemic cerebrovascular disease in Henan Han population |
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| LI Ai-fan,XU Yu-ming,ZHENG Hong,et al.. Association between variabe number of tandem repeat polymorphism of endothelial nitric oxide synthase gene and ischemic cerebrovascular disease in Henan Han population[J]. Journal of Apoplexy and Nervous Diseases, 2011, 28(5) | |
| Authors: | LI Ai-fan XU Yu-ming ZHENG Hong et al. |
| Affiliation: | LI Ai-fan,XU Yu-ming,ZHENG Hong,et al.(Department of Neurology,the First Affiliated Hospital,Zhengzhou University,Zheng zhou 450052,China) |
| Abstract: | Objective To investigate the association between variable number of tandem repeat(VNTR)polymorphisms of endothelial nitric oxide synthase(eNOS)gene and ischemic cerebrovascular disease(ICVD)in Henan Han population.Methods The genotypes of 488 patients with ICVD were detected by polymerase chain reaction(PCR)and compared with control group.Result The ab genotype distribution frequency of eNOS in patient group(18.4%)was higher than that in control group(13.57%)and the frequency of a alleles of eNOS gene in pa... |
| Keywords: | Nitric oxide synthase Gene polymorphism Ischemic cerebrovascular disease |
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