肺炎克雷伯菌医院感染及耐药性监测

目的:调查医院肺炎克雷伯菌的耐药现状,为临床合理用药提供依据。方法:用K-B法做体外药敏试验,用纸片确证法检测产超广谱β-内酰胺酶(ESBLs)细菌。结果:医院肺炎克雷伯菌产ESBLs率为27.3%;132株肺炎克雷伯菌对亚胺培南100%敏感,对头孢类抗生素,如头孢他啶、头孢曲松、头孢吡肟、头孢唑啉的耐药率分别为44.1%、48.7%、39.6%和66.9%。结论:医院应重视肺炎克雷伯菌的耐药监测,以预防医院感染的发生与爆发流行。

Drug resistance status and nosocomial infections of Klebsiella pneumoniae in our hospital

Objective:To investigate drug resistance status of Klebsiella pneumoniae and offer scientific basis for reasonable usage of antibiotics.Methods:Drug resistance was analyzed by using K-B method.The ESBLs producing strains detected by disc confirmed test.Results:The frequency of ESBLs producing Klebsiella pneumoniae isolates was 27.3% in our hospital.All of the 132 strains were susceptible to imipenem.The resistant rates to ceftazidine,ceftriaxone,cefepime,cefazolin were 44.1%,48.7%,39.6%,66.9%,respectively.Conclution:It is important to supervise drug resistance of clinical isolates in hospital and prevent nosocomial outbreak and surveillance.