胶质瘤中MMPs酶活性和肿瘤分级相关性的研究

目的 探讨基质金属蛋白酶2(MMP-2)与基质金属蛋白酶9(MMP-9)的活性与胶质瘤临床分级之间的关系.方法 采用明胶酶谱50例人脑胶质瘤与4例正常脑组织中的MMP-2及MMP-9进行检测.结果 在各级别组中,MMP-2和MMP-9的酶原形式无差别;随着胶质瘤恶性程度的增加,MMP-2和MMP-9的活化酶含量显著增加.结论 在不同恶性级别的人脑胶质瘤中,MMP-2和MMP-9酶活性发生改变,这些改变具有显著临床意义.

Study on Correlation with Enzymatic Activity of MMPs and Gliomas Stages

Objective To investigate the relationship between the expressions and expressions activities for type IV collagenase (including matrix metalloproteinase 2, MMP-2 and matrix metalloproteinase 9, MMP-9) and the clinical grades of human brain gliomas.Methods The enzymatic activities of MMP-2 and MMP-9 were detected by gelatin zymography in 50 cases of human brain gliomas and 4 cases of normal human brain tissue. Results In gelatin zymagraphy, the latent zymogen form of MMP-2 and MMP-9 were significantly elevated with the malignant grade of the gliomas. Conclusion The overexpression of MMP-2 and MMP-9 is associated with the malignant progression of gliomas, which have an important clinical significance.