白芍总苷对全脑缺血再灌损伤的保护作用

目的　研究白芍总苷 (TGP)对全脑缺血再灌损伤的保护作用及其作用机制。方法　采用大鼠三血管阻断全脑缺血再灌损伤模型 ,观察大鼠眼球颜色、脑组织SOD活性、MDA含量及病理组织学变化。结果　TGP(10、2 0、4 0mg·kg-1)可以明显改善大鼠眼球颜色的变化 ;TGP(2 0mg·kg-1)能提高脑缺血再灌大鼠大脑皮层、海马、纹状体中降低的SOD活性 ,并且降低升高的MDA含量 ;TGP(2 0mg·kg-1)对大鼠缺血性脑组织的病理组织学改变具有较好的保护作用。结论　TGP对缺血再灌注脑损伤具有明显的保护作用 ,此作用可能与其抗氧化有关。

Protective effect of TGP on complete cerebral ischemia reperfusion injury in rats

AIM To study the protective effect of total glucosides of paeony(TGP)on complete cerebral ischemia reporfusion injury and its mechanism of action.METHODS A complete cerebral ischemia[FQ(10。46,X-WZ]- reperfusion model of rats was induced by clipping three arteries. The changes in eye colour, SOD activity, MDA contents and histopathological characteristics were observed. RESULTS TGP (TGP 10、20、40 mg·kg -1 ) markedly reduced the change of eye colour; TGP(20 mg·kg -1 ) obviously elevated SOD activity decreased and inhibited the MDA of increased contents of cerebral cortex, hippocampus and corpus striatum of cerebral ischemia reperfusion in rats; TGP(20 mg·kg -1 )possessed protective effects on the histopathological changes of ischemia cerebral tissues in rats. CONCLUSION TGP possessed obvious protective effects on the cerebral ischemia reperfusion injury, suggesting that the protective action of TGP is relative to anti-oxidative action.-