住院2型糖尿病患者甲状腺过氧化物酶抗体阳性与阴性的分析

目的 探讨住院2型糖尿病（T2DM）患者甲状腺过氧化物酶抗体（TPO-Ab）阳性和阴性临床及生化特征的情况.方法 对1508例T2DM患者进行TPO-Ab检测,对抗体阳性组与阴性组临床及生化指标进行比较.结果 ⑴TPO-Ab阳性的T2DM患者甲状腺功能异常率[17.3%（38/220）]明显高于TPO-Ab阴性的T2DM患者[8.2%（105/1288）,χ2＝18.21,P＜0.01].⑵TPO-Ab阳性与阴性的T2DM患者临床特征比较：TPO-Ab阳性的T2DM患者自身免疫甲状腺炎（AIT）诊断率[15.45%（34/220）]高于TPO-Ab阴性的T2DM患者[1.32%（17/1288）,χ2＝114.89,P＜0.01）,TPO-Ab阳性的T2DM患者中女性高于男性[1：2.24（68/152）,χ2＝31.31,P＜0.01],TPO-Ab阴性的T2DM患者男女构成比[1：1.09（616/672）]比较差异无统计学意义（χ2＝2.35,P＞0.05）,而年龄、发病年龄、病程、体质量指数（BMI）、胰岛素治疗率、空腹C肽、餐后2 h C肽、促甲状腺素（uTSH）异常率和亚临床甲状腺功能异常率比较差异均无统计学意义（P＞0.05）.结论 ⑴T2DM患者TPO-Ab阳性者甲状腺功能异常明显高于TPO-Ab阴性者.⑵TPO-Ab阳性的T2DM患者以女性居多,而TPO-Ab阴性的T2DM患者性别无差异.⑶TPO-Ab阳性的T2DM患者AIT诊断率明显高于TPO-Ab阴性的T2DM患者.

The positive or negative prevalence of thyroid peroxidase antibody of the type 2 diabetic in-patients

Objective To investigate the positive and negative prevalence of thyroid peroxidase antibody （TPO-Ab） of the 1508 type 2 diabetic in-patients. Methods A total of 1508 patients with type 2 diabetes mellitus（T2DM） was enrolled in the study, and levels of TPO-Ab were measured. All the patients were divided into antibody positive and negative groups. Blood biochemical indi- cators and clinical characteristics were compared between two groups. Results （1）The rate of thyroid dysfunction in the positive of TPO-Ab in T2DM patients was 17. 3% （38/220）. The rate of thyroid dysfunction in the negative of TPO-Ab in T2DM patients was 8.2% （105/1288） （ X^2 = 18. 21, P 〈 0. 01 ）. （2）The diagnostic rate of antoimmune thyroiditis （AIT） and the rate of sexual had signif- icant difference in the positive [ 15.45% （34/220） ] and negative [ 1.32% （ 17/1288 ）, X^2 = 114. 89, P 〈 0, 01 ] of TPO-Ab in T2DM groups. The women were more than the men in the positive of TPO-Ab in T2DM groups [ 1 ： 2. 24 （68/152） , X^2 = 31.31, P 〈 0. O1 ]. There was no significant difference in the negative of TPO-Ab in T2DM groups in the proportion of men and women [ 1 ： 1.09 （616/672） , X^2 = 2. 35, P 〉 0. 05 ]. There was no significant difference in the positive and negative of TPO-Ab in T2DM groups in the clinical feature of age, course of disease, body mass index （ BMI）, the rate of insulin treatment, C peptide of not eating, C peptide of 2 hours after eating, the unusual rate of antithyroid glububin antibody （s-TSH）, and subclinical hypothyroidism（ P 〉 0. 05 ）. Conclu- sions （1）The rate of thyroid dysfunction in the positive of TPO-Ab in T2DM patients was clearly higher than that of the negative gourp. （2）There was significant difference in the rate of sexual of the positive of TPO-Ab in T2DM groups. There were significantly more females than males. There was no significant difference in the rate of sexual of the negative of TPO-Ab in T2DM groups. （3） The diagnos- tic rate of AIT in the positive of TPO-Ab in T2DM groups was significantly higher than that of the negative of TPO-Ab in T2DM groups.