奥扎格雷钠治疗急性脑梗死的临床疗效及难血浆炎性因子水平的影响

目的探讨奥扎格雷钠治疗急性脑梗死的临床疗效及对患者血浆炎性因子水平的影响。方法将56例急性脑梗死患者随机分为治疗组和对照组，各28例。治疗组在常规治疗的基础上给予奥扎格雷钠静脉滴注，同时口服阿司匹林．对照组在常规治疗基础上仅给予阿司匹林口服，两组均连续治疗2周后进行疗效评价；于治疗前后分别测定患者血浆炎性因子白细胞介素-6（IL-6）、白细胞介素-8（IL-8）和肿瘤坏死因子-α（TNF-α）水平。结果治疗组痊愈率为39．28％，总有效率为92．86％；对照组痊愈率为21．43％，总有效率为78．57％，治疗组的痊愈率和总有效率均明显高于对照组．具有统计学意义（P〈O．05）。治疗2周后，两组血浆IL-6、IL-8、TNF-d水平均较本组治疗前明显降低，其中治疗组有极显著性差异（P〈0．01）．对照组有显著性差异（19〈0．05）；治疗后，治疗组血浆IL-6、IL-8、TNF-α水平均明显低于对照组（P〈0．05）。结论奥扎格雷钠治疗急性脑梗死临床疗效确切，可显著降低患者神经功能缺损评分，较好的恢复神经功能，值得临床推广应用。

Clinical efficacy of sodium ozagrel to acute cerebral infarction and its influence on patients, inflammatory factors in blood plasma

Objective To explore the therapeutic effect of sodium ozagrel to acute cerebral infarction and its influence on patients,inflammatory factors in blood plasma.Methods Fifty-six patients with acute cerebral infarction were enrolled into our study and were randomly divided into two groups:twenty-eight patients were treated with sodium ozagrel 80mg ivgtt qd ×14 d,NS 250 mL plus ASA 0.1 g po qd × 14 d as tested group;while twenty-eight patients in the control group who were treated with ASA 0.1g po qd × 14 d ;The effectiveness was evaluated according to the nervous defect standard(NDS) after 14 d,s treatment;The level of IL-6、IL-8 and TNF-α in all patients,blood plasma were determined the day before and 14 days after treatment.Results After two weeks treatment,The general effective rate of the therapeutic group and the control one was92.86% and 78.57% respectively,the former is much higher than the latter with statistical significance(P<0.01 or P<0.05);Compared to pretreatment,the level of IL-6、IL-8 and TNF-α in blood plasma decreased significantly in both group,and those of therapeutic group were much lower than that of control group after 14days treatment(P<0.05).Conclusion The curative effect of sodium ozagrel combined with aspirin is satisfied,which can decrease canneurologic impairment grade of acute cerebral infarction patients,and is deserved of extended applyment.