| 丹芪降压冲剂对二肾一夹型高血压大鼠血压的影响及其机理研究 |
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| 引用本文： | 徐俊斌,陈宝田. 丹芪降压冲剂对二肾一夹型高血压大鼠血压的影响及其机理研究[J]. 中国中西医结合杂志, 2003, 0(Z1) |
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| 作者姓名： | 徐俊斌 陈宝田 |
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| 作者单位： | [1]解放军第187医院传染科 [2]第一军医大学南方医院 （海口571159） |
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| 摘 要： | 目的:研究丹芪降压冲剂对二肾一夹型高血压大鼠血压的影响和可能机制。方法:建立二肾一夹型高血压大鼠模型,随机分为假手术组、高血压对照组、中药低剂量组、中药高剂量组、开搏通组,用放免法测定血浆肾素活性(PRA)、血管紧张素Ⅱ(AngⅡ)、β-内啡肽(β-EP)和精氨酸加压素(AVP)浓度。结果:造模后大鼠血压升高;与假手术组比较,血浆 PRA、AngⅡ略升高,差异无显著性(P>0.05),血浆β-EP 降低,AVP 升高(P<0.05)。各给药组治疗后血压明显下降(P<0.05);各组治疗后高血压大鼠血浆 Ang Ⅱ、AVP降低,β-EP 升高(P<0.05)。结论:丹芪降压冲剂有降压作用,其机理可能与升高血浆β-EP,降低血浆 AVP、AngⅡ有关。
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| 关 键 词： | 丹芪降压冲剂 血压 β-内啡肽 二肾一夹型高血压大鼠 血浆肾素活性 血管紧张素Ⅱ 精氨酸加压素 |
Effect of Danqi Hypotensive Granule on Blood Pressure in Two-kidney,One-clip Hypertensive Rats and Its Mechanism |
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| XU Jun-bin,CHEN Bao-tian. Effect of Danqi Hypotensive Granule on Blood Pressure in Two-kidney,One-clip Hypertensive Rats and Its Mechanism[J]. Chinese journal of integrated traditional and Western medicine, 2003, 0(Z1) |
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| Authors: | XU Jun-bin CHEN Bao-tian |
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| Affiliation: | Department of Infectious Diseases; The 187 Hospital of PLA; Haikou(571159); |
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| Abstract: | Objective:To study the effect of Danqi Hypotensive Granule (DHG) on blood pressure in two-kidney,one-clip hypertensive rats and its possible mechanism.Methods:Two-kidney,one-clip hypertensive rats model was set up.Rats were randomly divided into the sham-operation group(group A),the control group (group B),TCM of low dosage group (group C),TCM of high dosage group (group D),captopril group(group E).Plasma renin activity (PRA),angiotensin Ⅱ(Ang Ⅱ),β-endorphin (β-EP)and arginine-va- sopressin(AVP)levels were ... |
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| Keywords: | Danqi Hypotensive Granule blood pressure β-endorphin two-kidney one-clip hypertensive rats plasma renin activity angiotensin Ⅱ arginine-vasopressin |
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