COPD急性加重期CRP、IL-10、WBC、中性粒细胞比例检测的意义及比较

目的探讨C反应蛋白（CRP）、白介素-10（IL-10）、白细胞（WBC）、中性粒细胞比例（N%）在慢性阻塞性肺疾病（COPD）急性加重期诊治中的临床意义。方法采用分析30例患者治疗前及自觉症状好转时血清CRP水平、IL-10、末梢血WBC总数、N%动态变化情况,观察上述指标在急性加重期的阳性率以及自觉症状好转时的阴性率。结果①CRP、IL-10、N%水平在WBC自觉症状好转时均明显低于COPD急性加重期（P均〈0.01）;②COPD患者急性加重期CRP、IL-10、N%阳性率均高于WBC阳性率,且与后者比较均具有统计学差异（P均〈0.01）;③COPD患者经治疗自觉症状好转时CRP、WBC阴性率均高于N%阴性率,且与后者比较均具有统计学差异（P均〈0.01）。结论血清CRP既可作为COPD患者急性加重期感染的敏感指标,又是反映急性加重期治疗效果的早期评判指标。

Clinical significance and comparison of CRP,WBC and N% in hospitalized patients with acute exacerbations of chronic obstructive pulmonary disease

Objective To study the clinical significance of C-reaction protein（CRP）,IL-10、white blood cell（WBC） counter and neutrophilgranulocyte ratio（N% ） in acute exacerbations of hospitalized patients with chronic obstructive pulmonary disease（COPD） .Methods The serum CRP levels,IL-10、the gross of WBC and N% were detected of the same 30 inpatients with acute exacerbations of COPD before treatment and after getting better.The masculine rates during acute exacerbations and the negative rates after getting better of abovementioned indexes were observed.Results ①The levers of CRP、IL-10、WBC and N% of patients after getting better were significantly lower than those before treatment（P〈0.01） .② The masculine rates of CRP、IL-10 and N% were higherthan that of WBC during acute exacerbations,and there were statistics differences between them（P〈0.01） .③The negative rates ofCRP、IL-10 and WBC were higher than that of N% after getting better,and there were statistics differences between them（P〈0.01） .Conclusion The serum CRP level is a sensitive index in COPD patients with acute exacerbations,and it is also a good index to judge the early therapeutic efficacy in COPD patients with acute exacerbations.