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| 抗轮状病毒卵黄免疫球蛋白的蛋白酶水解及被动免… | |
| 引用本文： | 龙中儿 钟青萍. 抗轮状病毒卵黄免疫球蛋白的蛋白酶水解及被动免…[J]. 中华实验和临床病毒学杂志, 1997, 11(4): 358-362 |
| 作者姓名： | 龙中儿 钟青萍 |
| 摘 要： | 用婴幼儿轮状病毒抗原免疫产卵母鸡，制备出抗婴幼儿轮状病毒鸡卵黄免疫球蛋白（抗－ＨＲＶＩｇＹ）同时研究抗－ＨＲＶＩｇＹ的抗人类胃酸屏障能力，抗消化道蛋白酶的酶解以及临床使用的安全性和效果，研究结果表明：抗－ＨＲＶＩｇＹ具有一定的抗胃酸屏障能力和抗消化道蛋白酶酶解作用，抗－ＨＲＶＩｇＹ安全无毒，对婴幼儿轮状病毒感染具有被动免疫保护作用。 |
| 关 键 词： | 轮状病毒 卵黄 免疫球蛋白 蛋白酶 腹泻 |
Studies on hydrolysis of anti-HRV IgY and its oral passive immunity effect to human rotavirus] |
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| Z Long,Q Zhong,Y Zhu,Y Xiong,H Chen,N Yang,R Yang. Studies on hydrolysis of anti-HRV IgY and its oral passive immunity effect to human rotavirus][J]. Chinese journal of experimental and clinical virology, 1997, 11(4): 358-362 | |
| Authors: | Z Long Q Zhong Y Zhu Y Xiong H Chen N Yang R Yang |
| Affiliation: | Sino-German Joint Reseach Institute, Nanchang 330047. |
| Abstract: | In this paper, hens of fine breed were immunized with human rotavirus (HRV), and the anti-HRV IgY was isolated and purified from their eggs collected daily. In addition, the resistance of anti-HRV IgY to hydrolysis of gastric juice and proteases in human digestive tract, the safety of IgY and the effectiveness of IgY in clinical use were observed as well. The results showed that anti-HRV IgY has a fairly good resistance to gastroinstestinal proteases. The safety of using anti-HRV IgY was affirmed by oral administration to mice of a solution of IgY. In clinical test the IgY has been proved to be anti-HRV and, therefore, effective against infections of infant diarrhea induced by HRV. |
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