全数字化乳腺X线摄影联合彩色多普勒超声对诊断微小乳腺癌的研究

目的 探讨全数字化乳腺X线摄影联合彩色多普勒超声(彩超)检查对微小乳腺癌的诊断价值.方法 66例直径≤1.5 cm的微小乳腺癌患者(恶性组)和20例直径≤1.5 cm的乳腺良性病变患者(良性组)均行全数字化乳腺X线摄影和彩超检查,进行定性诊断,最后与手术病理结果对照.结果 恶性组:全数字化乳腺X线摄影诊断微小乳腺癌55例,其敏感度和特异度分别为83.3%(55,66)、90.0%(18/20),准确度为84.9%(73,86);彩超诊断微小乳腺癌52例,其敏感度和特异度分别为78.8%(52/66)、75.0%(15/20),准确度为77.9%(67/86);二者联合诊断微小乳腺癌65例,其敏感度和特异度分别为98.5%(65/66)、100.0%(20/20),准确度为98.8%(85/86).与单一检查比较差异有统计学意义(P＜0.05).恶性组收缩期峰值流速及血流阻力指数均高于良性组,差异有统计学意义(P＜0.05).结论 对微小乳腺癌定性诊断方面,全数字化乳腺X线摄影为首选,彩超对良恶性结节鉴别诊断有一定帮助,二者联合应用可提高微小乳腺癌的检出率和准确度.

A study on color Doppler sonography combined with digital mammography for micro breast cancer screening

Objective To evaluate the efficacy of color Doppler sonography combined with digital mammography for micro breast cancer screening.Methods Both of color Doppler sonography and digital mammography were performed in 66 patients with micro breast cancer less than 1.5 cm in diameter and 20 patients with benign lesion less than 1.5 cm in diameter.The images of sonography and mammography were analyzed respectively.A comparative study on the results of sonography,mammography and pathological finding of specimen in breast lesions was made.Results Fifty-five of 66 Cases with micro breast cancer were detected by digital mammography.52 of 66 cases by color Doppler sonography and 65 of 66 cases by sonography combined with mammography.The color Doppler sonography combined with digital mammography provided higher sensitivity,specificity and accuracy[98.5%(65/66),100.0%(20/20)and 98.8%(85/86)respectively]than color Doppler sonography[78.8%(52/66),75.0%(15/20),77.9% (67/86)respectively]and digital mammography alone[83.3%(55/66),90.0%(18/20)and 84.9%(73/86)respectively](P＜0.05).The peak flow velocities and the mean resistant index were higher in malignant lesion than those in benign lesion(P＜0.05).Conclusions The color Doppler sonography combined with digital mammography can increase the sensitivity and accuracy of diagnosing micro breast cancer.Digital mammography is recommended to identify micro breast cancer.It is helpful of color Doppler sonography in differentiation of benign and malignant breast lesion.