Anosmia differently affects the reproductive hormonal pattern in sexually experienced and inexperienced male rats |
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| Authors: | F. Dessi-Fulgheri L.-G. Dahlöf K. Larsson C. Lupo Di Prisco S. Tozzi |
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| Affiliation: | 1. Instituto di Zoologia, Universita di Firenze, Italy;2. Department of Psychology, Unit of Psychobiology, University of Göteborg, Sweden;3. Instituto di Fisiologia umana, Universita di Siena, Italy |
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| Abstract: | ![]()
Effects of anosmia induced by surgical destruction of the olfactory epithelium were studied on testosterone (T), estradiol (E2), 5α-dihydro-testosterone (DHT) and corticosterone secretion and hypothalamic T metabolism in male Wistar rats, part of which were sexually experienced and part of which were sexually inexperienced. Anosmia was followed by decreased T and E2 plasma levels and increased DHT and corticosterone levels in experienced animals. In inexperienced rats, anosmia caused increased DHT levels. Experience decreased E2 and increased corticosterone levels in anosmic rats, whereas in intact rats, experience caused increased T and DHT levels. Anosmia increased brain aromatization activity in experienced rats. Experience increased the formation of androstenediol in anosmic as well as in intact rats and caused a decrease in the formation of brain E2 in intact rats. The results obtained suggest that odoriferous stimuli may influence T, E2, DHT and corticosterone secretion and T aromatization provided such stimuli are associated with previous sexual experience. |
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| Keywords: | Anosmia Male rat Testosterone secretion Testosterone metabolism Aromatization Sexual experience |
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