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| 川芎嗪脂质体的制备和质量评价 | |
| 引用本文： | 范广俊,范青,冷东伟. 川芎嗪脂质体的制备和质量评价[J]. 药学服务与研究, 2008, 8(6): 453-455 |
| 作者姓名： | 范广俊 范青 冷东伟 |
| 作者单位： | 大连医科大学附属二院药剂科,大连116027 |
| 摘 要： | 目的：制备川芎嗪脂质体，考察其理化性质。方法：以磷脂-胆固醇（2．5：1．5）为包封膜材，采用注入乳匀法制备川芎嗪脂质体，观察脂质体形态，测定其粒径，采用HPLC法测定川芎嗪含量，并考察其包封率、载药量和稳定性。结果：川芎嗪脂质体平均粒径为200nm，包封率和载药量分别为（39．5±0．66）％和（0．719±0．011）％。4℃保存30d稳定。结论：以本方法制备的川芎嗪脂质体质量符合《中华人民共和国药典》的要求。 |
| 关 键 词： | 川芎嗪 脂质体 工艺学 制药 质量控制 |
Preparation and quality evaluation of ligustrazine liposomes |
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| FAN Guang-jun,FAN Qing,LENG Dong-wei. Preparation and quality evaluation of ligustrazine liposomes[J]. Pharmaceutical Care and Research, 2008, 8(6): 453-455 | |
| Authors: | FAN Guang-jun FAN Qing LENG Dong-wei |
| Affiliation: | (Department of Pharmacy, the 2nd Hospital affiliated to Dalian Medical University, Dalian 116027, China) |
| Abstract: | Objective： To prepare ligustrazine liposomes and investigate its physicochemical properties. Methods： The ligustrazine liposomes were prepared by homogenization injection method, phospholipid-eholesterol（2.5： 1.5） as encapsulating film. The morphology and diameter were detected by transmission electron microscope. The content of ligustrazine was determined by HPLC method. Entrapment efficiency,drug loading and stability of ligustrazine liposomes were investigated. Results： The mean diameter of ligustrazine liposomes was 200 nm. The entrapment efficiency was （39.54±0.66）% and the drug loading was （0. 719 ±0.011）%. The liposomes were stable at the temperature of 4℃ for 30 d. Conclusion：The ligustrazine liposomes prepared by this method are up to the standard of Pharmacopeia of People＇s Republic of China （2005 edition）. |
| Keywords: | tetramethyl pyrazine liposomes technology, pharmaceutical quality control |
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