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| 纯氧吸入后正常大鼠脑组织BOLD信号变化 | |
| 引用本文： | 高欣,刘士远,陶晓峰,岳秀慧,蒯新平. 纯氧吸入后正常大鼠脑组织BOLD信号变化[J]. 华南国防医学杂志, 2010, 24(5): 331-334 |
| 作者姓名： | 高欣 刘士远 陶晓峰 岳秀慧 蒯新平 |
| 作者单位： | 第二军医大学附属长征医院影像和核医学科,上海,200003;第二军医大学附属长征医院影像和核医学科,上海,200003;第二军医大学附属长征医院影像和核医学科,上海,200003;第二军医大学附属长征医院影像和核医学科,上海,200003;第二军医大学附属长征医院影像和核医学科,上海,200003 |
| 基金项目： | 国家自然科学基金项目，上海市科委重点课题基金，上海市科委医学重点基金 |
| 摘 要： | 目的探讨不同时间长度吸入100%氧气后,引起正常大鼠脑组织血氧水平依赖（blood oxygen level-de-pendent,BOLD）信号变化的原因。方法正常雄性SD大鼠11只,在7T超高场磁共振扫描仪下,采用BOLD-fMRI序列扫描。比较短时间吸入空气和不同时间长度吸入100%氧气后皮层、尾状核、海马、丘脑的BOLD信号差异。采用同样的大鼠8只以灌注成像序列扫描比较脑血流量（cerebral blood flow,CBF）的变化。结果短时间吸入空气、短时间吸入100%氧气和长时间吸入100%氧气产生的BOLD信号变化具有统计学差异（P〈0.001）。吸入100%氧气导致BOLD信号显著升高,皮层脑血流量的下降更为明显。结论吸入100%氧气可以有效地产生BOLD信号对比,长时间吸入100%氧气后BOLD信号变化更明显;BOLD信号的升高与血氧饱和度有关。 |
| 关 键 词： | 氧 大鼠 血氧水平依赖 磁共振成像 |
BOLD Signal Changes in Brain Tissues of Normal Rats after Inhaling Pure Oxygen |
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| GAO Xin,LIU Shi-yuan,TAO Xiao-feng,YUE Xiu-hui,JIN Xin-ping. BOLD Signal Changes in Brain Tissues of Normal Rats after Inhaling Pure Oxygen[J]. Military Medical Journal of South China, 2010, 24(5): 331-334 | |
| Authors: | GAO Xin LIU Shi-yuan TAO Xiao-feng YUE Xiu-hui JIN Xin-ping |
| Affiliation: | GAO Xin,LIU Shi-yuan,TAO Xiao-feng,YUE Xiu-hui,JIN Xin-ping.Department of Medical Imaging and Nuclear Medicine,the Affiliated Changzheng Hospital of the Second Military Medical University,Shanghai 200003,China |
| Abstract: | Objective To explore the impact of the pure oxygen on the blood oxygen level-dependent (BOLD) signal intensity of the rat brain after inhaling pure oxygen with different durations.Methods Eleven male SD rats weighting 200~250 g were examined using BOLD-fMRI sequence with 7T magnetic resonance scanner.The BOLD signal intensity of cortex,caudate,hippocampus and thalamus after inhaling pure oxygen with different durations were compared respectively.Changes in cerebral blood flow (CBF) in eight same rats were c... |
| Keywords: | Oxygen Rat Blood oxygen level-dependent Magnetic resonance imaging |
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