| 三氧化二砷对肿瘤血管内皮细胞作用的研究 |
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| 引用本文： | 傅文达,王雪雯,张建华.三氧化二砷对肿瘤血管内皮细胞作用的研究[J].农垦医学,2011,33(2):130-135. |
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| 作者姓名： | 傅文达 王雪雯 张建华 |
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| 作者单位： | 石河子大学医学院病理生理学教研室/新疆地方与民族高发病教育部重点实验室,新疆石河子,832002 |
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| 摘 要： | 目的：探讨三氧化二砷（As2O3）对肿瘤血管内皮细胞生长和功能的抑制作用及其相关的抗血管形成机制。方法：采用肝癌HepG2细胞上清诱导人脐静脉内皮细胞（human umbilical vein endothelial cells,HUVEC）成为肿瘤血管内皮细胞（tumor-derived endothelial cells,Td-EC）,通过细胞迁徙实验流式细胞术、流式细胞术、血管形成实验检测As2O3对Td-EC细胞生物学特征的影响。结果：As2O3在体外对Td-EC有显著促进凋亡的作用,并能抑制其迁移和血管的形成,较在同样条件下对HUVEC的凋亡、迁移和血管形成作用显著。结论：As2O3在体外可特异地抑制Td-EC生长及功能。
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| 关 键 词： | As2O3 肿瘤血管内皮细胞 凋亡 迁移 血管形成 |
Arsenic trioxide on tumor vascular endothelial cell in vitro |
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| FU Wen-da,WANG Xue-wen,ZHANG Jian-hua.Arsenic trioxide on tumor vascular endothelial cell in vitro[J].Agricultural Reclamation Medicine,2011,33(2):130-135. |
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| Authors: | FU Wen-da WANG Xue-wen ZHANG Jian-hua |
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| Institution: | FU Wen-da,WANG Xue-wen,ZHANG Jian-hua(Shihezi University School of Medicine Department of Pathophysiology/ Ministry of Education Key Laboratory of Xinjiang Endemic and Ethnologic High lncidence Disease,Xinjiang Shihezi,832002) |
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| Abstract: | Objective:Arsenic trioxide(As2O3) on tumor vascular endothelial cell growth and function of inhibition and its related anti-angiogenic mechanism. Methods:The cells differentiated into tumor-derived endothelial cells(Td-ECs) by co-culturing with supernatants of HepG2 cells,The anti-effect of As2O3 on Td-ECs was detected with cell migration,flow cytometry experiments,flow cytometry,blood vessel formation assay. Results:As2O3 Td-EC in vitro significantly promote apoptosis,and inhibited their migration and bloo... |
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| Keywords: | As2O3 |
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