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| N-末端脑钠肽前体在舒张性心力衰竭患者中的表达水平 | |
| 引用本文： | 徐雪姣. N-末端脑钠肽前体在舒张性心力衰竭患者中的表达水平[J]. 中国临床医学, 2011, 18(3): 317-319 |
| 作者姓名： | 徐雪姣 |
| 作者单位： | 上海市闸北区北站医院心血管内科,上海,200070 |
| 摘 要： | 目的：探讨血浆N-末端脑钠肽前体（NT-proBNP）在舒张性心力衰竭诊断及疗效评价中的应用价值。方法：80例心力衰竭住院患者,其中收缩性心力衰竭（SHF）42例,舒张性心力衰竭（DHF）38例,另选20例心功能正常者作为对照组。对所有研究对象检查超声心动图、定量检测血浆NT-proBNP;将DHF组患者随机分为A组（18例）和B组（20例）,A组接受常规心力衰竭治疗,B组在常规治疗基础上加用倍他洛克治疗;6个月后复查血浆NT-proBNP和超声心动图,比较治疗前后各项指标的差异。结果：DHF组左室舒张末内径（LVEDD）、左室收缩末内径（LVESD）及左室射血分数（LVEF）与对照组比较均无显著差异,E/A值却显著低于对照组（P〈0.01）;SHF组和DHF组NT-proBNP水平均显著高于对照组（P〈0.01）。DHF患者血浆NT-proBNP值与E/A值呈负相关（r=-0.687,P〈0.01）。加用倍他洛克治疗后,DHF患者E/A值显著高于常规治疗组,NT-proBNP则显著低于常规治疗组（P〈0.01）。结论：血浆NT-proBNP值在DHF的诊断和疗效评估中具有重要价值,在常规抗心衰治疗基础上加用β-受体阻滞剂可显著改善左室舒张功能。 |
| 关 键 词： | N-末端脑钠肽前体 舒张性心力衰竭 β-受体阻滞剂 |
The Expression Level of N-terminal Pro-Brain Natriuretic Peptide in Patient with Diastolic Heart Failure |
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| XU Xuejiao. The Expression Level of N-terminal Pro-Brain Natriuretic Peptide in Patient with Diastolic Heart Failure[J]. Chinese Journal Of Clinical Medicine, 2011, 18(3): 317-319 | |
| Authors: | XU Xuejiao |
| Affiliation: | XU Xuejiao Department of Cardiovascular Medicine,Beizhan Hospital in Zhabei District,Shanghai 200070,China |
| Abstract: | Objective:To study the diagnostic and treatment value of N-terminal pro-brain natriuretic peptide(NT-proBNP) in diastolic heart failure(DHF).Methods:A total of 80 patients diagnosed as chronic heart failure were entrolled,including 42 cases with systolic heart failure(SHF) and 38 cases with diastolic heart failure(DHF);another 20 cases with nomal cardiac function were included as control group.Echocardiography was performed and serum NT-proBNP levels were measured for all the subjects.The 38 cases with DHF ... |
| Keywords: | N-terminal pro-brain natriuretic peptide Diastolic heart failure β-blocker |
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