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| 荧光原位杂交与免疫组化检测结直肠癌组织HER-2基因扩增或蛋白表达情况的研究 | |
| 引用本文： | 王玉环,孙振柱,张恒明,孔艳青. 荧光原位杂交与免疫组化检测结直肠癌组织HER-2基因扩增或蛋白表达情况的研究[J]. 农垦医学, 2011, 33(2): 97-101 |
| 作者姓名： | 王玉环 孙振柱 张恒明 孔艳青 |
| 作者单位： | 1. 石河子大学医学院,新疆石河子,832002 2. 新疆维吾尔自治区人民医院病理科,乌鲁木齐,830001 |
| 摘 要： | 目的:用免疫组化(IHC)和荧光原位杂交技术(FISH)检测结直肠癌组织中HER-2蛋白表达或基因扩增状况,探讨HER-2在结直肠癌中的表达及临床意义.方法:采用IHC EnVision法检测68例结直肠癌及40例癌旁粘膜组织中HER-2蛋白的表达情况,并分析其与结直肠癌临床病理特征和预后的关系;对IHC(++)和(+... |
| 关 键 词： | 结直肠癌 HER-2 荧光原位杂交 免疫组化 |
Study of the Methods of Fluorescence in Situ Hybridization and Immunohi stochemistry in Detecting HER-2 in Colorectal Cancer |
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| WANG Yu-huan,SUN Zhen-zhu,ZHANG Heng-ming,KONG Yang-qing. Study of the Methods of Fluorescence in Situ Hybridization and Immunohi stochemistry in Detecting HER-2 in Colorectal Cancer[J]. Agricultural Reclamation Medicine, 2011, 33(2): 97-101 | |
| Authors: | WANG Yu-huan SUN Zhen-zhu ZHANG Heng-ming KONG Yang-qing |
| Affiliation: | WANG Yu-huan1,SUN Zhen-zhu2,ZHANG Heng-ming2,KONG Yang-qing2(1.Shihezi University School of Medicine,Xinjiang Shihezi,832002,2.Pathology Department of People's Hospital of Xinjiang Uygur Autonomous Region,Urumqi,830001) |
| Abstract: | Objective:To detect HER-2 expression in colorectal cancer tissues using immunohistochemistry(IHC) and fluorescence in situ hybridization(FISH),to analyze the significance of HER-2 expression in colorectal cancer. Methods:The expression of HER-2 protein in 68 cases of colorectal cancer and 40 cases of peri-cancer mucosa was detected by EnVision IHC.The correlations of HER-2 expression with clinicopathological parameters and prognosis in colorectal cancer were analyzed.15 cases of positive(++) and(+++) by IHC... |
| Keywords: | HER-2 |
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