脐带间充质干细胞经肝动脉灌注治疗失代偿期肝硬化患者

目的 观察人脐带间充质干细胞治疗失代偿期肝硬化患者的有效性.方法 失代偿期乙型肝炎肝硬化患者10例,经肝动脉灌注人脐带间充质干细胞2×107个.比较患者在移植前及移植后1、4、8、12、24周肝功能以及临床病情的变化情况.结果 随访过程中,患者乏力、尿少、水肿症状在第1～2周即明显缓解,食欲较术前明显增加,腹水消退快,...

The efficacy of human umbilical cord mesenchymal stem cells transplantation in patients with decompensated cirrhosis after hepatitis

Objective To observe the safety and efficacy of human umbilical cord mesenchymal stem cells transplantation in patients with decompensated cirrhosis after hepatitis B.Methods Ten patients were included in the study.All patients were administered 2×107 human umbilical cord mesenchymal stem cells（hUC-MSCs） via intrahepatic arterial infusion.Changes of symptoms and liver function at 1,4,8,12,24 weeks were evaluated.Results During the follow-up,symptoms such as weak,oliguresis,abdominal distention and edema released within 2 weeks.Appetite increased and abdominal distention improved significantly within 2-6 weeks.The frequency of conscious disturbance in patients complicated with hepatic encephalopathy decreased.Most of patients have released conscious disturbance during the treatment.All the patients have no history of supplementing albumin,blood plasma and have no need for treating coma.Conclusion hUC-MSCs for decompensated cirrhosis patients is effective and its long-term efficacy is needed to study.