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P57kip2在皮肤血管瘤中的表达及意义
引用本文:杨勇,刘平,张端莲,陕声国,张杰. P57kip2在皮肤血管瘤中的表达及意义[J]. 武汉大学学报(医学版), 2008, 29(1): 48-50,I0002
作者姓名:杨勇  刘平  张端莲  陕声国  张杰
作者单位:武汉大学医学院医学遗传学系,湖北,武汉,430071;武汉大学医学院组织胚胎学与胚胎学教研室,湖北,武汉,430071;武汉大学人民医院整形外科,湖北,武汉,430060
基金项目:国家自然科学基金 , 湖北省科技厅科研项目 , 湖北省卫生厅科研项目
摘    要:目的:探讨P57kip2蛋白在血管瘤发生、发展及退化过程中的表达状况及意义。方法:采用免疫组织化学方法(SP法)检测人皮肤血管瘤增生期、退化期及正常皮肤组织中P57kip2的表达水平,并结合第Ⅷ因子相关抗原的免疫组织化学染色证实表达P57kip2的细胞是血管内皮细胞。利用计算机图像分析技术测量不同时期血管瘤组织和正常皮肤组织P57kip2表达的平均光密度和平均阳性面积率。结果::P57kip2在增生期血管瘤内皮细胞的表达低于退化期,差异有显著性(P<0.005);退化期血管瘤内皮细胞P57kip2表达水平与正常组织相比,差异有显著性(P<0.05)。结论:P57kip2蛋白在血管退化期可能发挥抑制血管瘤内皮细胞增殖的作用,与血管瘤的消退有一定的关系。

关 键 词:血管瘤  P57kip2  内皮细胞
文章编号:1671-8852(2008)01-0048-03
收稿时间:2007-03-14
修稿时间:2007-03-14

Expression of P57kip2 Protein in Human Dermal Hemangiomas and Its Significance
YANG Yong,LIU Ping,ZHANG Duanlian,SHAN Shengguo,ZHANG Jie. Expression of P57kip2 Protein in Human Dermal Hemangiomas and Its Significance[J]. Medical Journal of Wuhan University, 2008, 29(1): 48-50,I0002
Authors:YANG Yong  LIU Ping  ZHANG Duanlian  SHAN Shengguo  ZHANG Jie
Abstract:Objective:To investigate the expression and significance of P57kip2 in the occurrence,development and regression of human hemangiomas.Methods:The expression of P57kip2 was examined in proliferating, involuting human hemangiomas and normal skin tissues by using immunohistochemical technique.Immunohistochemical technique for factor Ⅷ-related antigen was used to identify that the cells which expressed P57kip2 were endothelia.Image analysis system was applied to measure the expression level of P57kip2 at different stage of hemangiomas and in normal skin tissues.Results:The expression of P57kip2 was significantly lower in proliferating hemangiomas than in involuting hemangioma tissues(P<0.005),and was lower in the involuting hemangiomas than in normal skin tissues(P<0.05).Conclusion:It is suggested that P57kip2 might play an important role in the occurrence,development and regression of human hemangiomas.
Keywords:Hemangioma  P57kip2  Endothelial Cells
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