Postoperative radiotherapy and radiotherapy combined with CCNU chemotherapy for treatment of brain gliomas |
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| Authors: | Tomasz Trojanowski Jerzy P\ceszyński Krzysztof Turowski Stanisław Kamiński Igor Gościński Marian Reinfus Tadeusz Krzyszkowski Marek Pyrich Adam Bielawski Czesława Leszczyk Barbara Bendarzewska Andrzej Staszczak Halina Koźniewska |
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| Institution: | (1) Department of Neurosurgery, Medical Academies in Lublin, Lublin;(2) Department of Neurosurgery, Medical Academies in Cracow, Cracow;(3) Department of Neurosurgery, Medical Academies in Warsaw, Warsaw;(4) Department of Radiotherapy, Lublin;(5) Department of Radiotherapy, Cracow;(6) Department of Radiotherapy, M. C. Sk odowska University in Lublin, Warsaw;(7) Department of Radiotherapy, Institute of Physics, Poland |
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| Abstract: | A prospective, randomized trial evaluates the effects of two postoperative treatment regimens on survival in 198 adult patients with supratentorial gliomas. All patients were irradiated with 6 000 rads after possibly radical removal of tumors. CCNU administration in the dosis of 100 mg/sq m of body surface every 6–8 weeks following surgery proved to have no significant effect on the survival of patients. The median survival time in patients receiving radiation therapy alone was 61±7 weeks, while in those receiving additional chemotherapy was 56±4 weeks. Tumor histological malignancy and patients age were found to be the only important prognostic factors, irrespective of the treatment modality.
Address for offprints: T Trojanowski, Department of Neurosurgery, Medical School, Jaczewskiego 8, 20-950 Lublin, Poland |
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| Keywords: | brain gliomas radiation therapy chemotherapy CCNU brain neoplasm |
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