局部晚期乳腺癌新辅助化疗疗效观察

目的比较2组不同化疗方案在局部晚期乳腺癌新辅助化疗中的疗效及毒副反应。方法80例Ⅱ、Ⅲ期乳腺癌随机分为2组，每组40例。A组应用CTF方案（环磷酰胺＋吡柔比星＋5-氟尿嘧啶），B组用CAF方案（环磷酰胺＋阿霉素＋5-氟尿嘧啶）新辅助化疗。完成3个周期新辅助化疗后评价疗效。结果A组总有效率为72．5％，B组的总有效率为65．0％，差异无统计学意义（P〉0．05）。两组不良反应中脱发和心电图指标改变，A组明显低于B组，有统计学差异，其余指标差异无显著性。结论2组新辅助化疗方案对乳腺癌治疗均有效，毒性反应均可耐受。CTF组疗效高于CAF组，THP可替代ADM在临床上应用。

The Study of Neoadjuvant Chemotherapy for Locally Advanced Breast Cancer

Objective To compare the efficacy and side effects of two different neoadjuvant chemotherapy regiments for the treatment of breast cancer. Methods 80 patients with stage II,III breast cancer were divided into two groups at random, and received CTF（ CTX, THP,5-Fu）, CAF（ CTX, ADM ,5-Fu）regimen for neoadjuvant chemotherapy. The clinical therapeutic effect was valuated after 3 cycles of neoadjuvant chemo therapy. Results The overall response rate （RR） of group A and group B were 72. 5 % and 65.0% respectively, without significant statistical difference （P 〉 0.05 ）. The incidence of adverse reactions in the group A （ alopecia and cardiac toxicity）was significantly lower than that in the control group （P 〈 0.05 ）. Conclusion Two different neoadjuvant chemotherapy regiments were both effective to the locally advanced breast cancer. But lower taxic reaction were observed in CTF group than CAF group. The taxic reaction were tolerated. THP can be widely used clinuically