不同年龄组缺血性脑卒中患者颈动脉斑块与相关因素分析

目的 探讨不同年龄组缺血性脑卒中患者颈动脉斑块情况及其相关因素分析.方法 收集我院神经内科的缺血性脑血管病患者228例,其中45岁以下青年组21例（男5例,女16例）,老年组207例（男120例,女87例）.同时完成颈动脉血管超声检查和血液学检查指标.结果 青年组和老年组比较,在总胆固醇（TC）、低密度脂蛋白（LDL-C）、血浆纤维蛋白原（FIB）、高敏C反应蛋白（hs-CRP）方面老年组明显升高,在血浆同型半胱氨酸（Hcy）方面青年组增高,差异有统计学意义（P〈0.05）.老年组分无斑块51例、稳定斑块165例和不稳定斑块12例,不同斑块组在hs-CRP和FIB方面有差异,有统计学意义（P〈0.05）.逐步回归分析法显示LDL-C、FIB和hs-CRP与颈动脉粥样硬化正相关.结论 LDL-C、高敏C反应蛋和FIB是动脉粥样硬化脑梗死的独立危险因素,在青年组血浆同型半胱氨酸是独立危险因素.

The analysis of carotid plaque and correlative factors in patients with ischemic stroke in different age groups

Objective To investigate the relationship in different age groups of carotid plaque and correlative factors in patients with ischemic stroke. Methods To collect 228 cases in our department of Neurology with ischemic cerebral vascular dis- ease. There are two groups, the young group is under 45 years old with 21 cases （5 men, 16 female）, the older group with 207 cases （ 120 men, 87 woman ）. All the cases were completed carotid artery ultrasound and blood examination. Results Compared with two groups, the levels of total cholesterol （ TC）, low density lipoprotein （ LDL-C）, Fibrinogen （FIB） and high sensitivity C-reactive protein （HS-CRP） in older group were increases, and the levels of plasma homocysteine （Hcy）in youth group were de- termined （P 〈 0. 05）. There were 51 cases of no plaques, 165 cases of stabilize plaque and 12 cases of unstable in older group, different plaque group differences in hs-CRP and FIB （P 〈 0. 05）. Stepwise regression analysis shows LDL-C, FIB and HS-CRP were associated with carotid atherosclerosis. Conclusion The levels of LDL-C, HS-CRP and FIB were the independent risk factor for atherosclerosis cerebral infarction, and the levels of Plasma homocysteine was an independent risk factor in youth groups.