肺心通对慢性肺源性心脏病模型大鼠一氧化氮、内皮素-1及血管内皮细胞生长因子的影响

目的：探讨肺心通对慢性肺源性心脏病（CPHD）大鼠的治疗效果及其作用机理。方法：50只Wistar大鼠，雌雄各半，随机分为空白组、模型组、肺心通高、中、低剂量组，以2％野百合碱（MCT）按60mg／kg1次腹腔注射复制CPHD大鼠模型。同时给模型组、肺心通高、中、低剂量组灌胃相应药物，连续用药21d。测定大鼠血清和肺组织匀浆中-氧化氮（NO）、内皮素-1（ET-1）的含量；测定肺小动脉及支气管平滑肌血管内皮细胞生长因子（VEGF）的表达；观察肺组织病理形态学改变。结果：肺心通可显著提高CPHD模型大鼠的NO含量；降低ET-1的含量；降低大鼠肺小动脉及支气管平滑肌中VEGF的表达；改善肺组织的病理改变。结论：肺心通对CPHD大鼠有较好的治疗作用。

Influence of Feixintong on the Contents of NO,ET-1 and VEGF in Rat Model of Chronic Pulmonary Heart Disease

Objective:To research the functionary mechanism and treating effect of Feixintong(FXT) on chronic pulmonary heart disease(CPHD).Methods:50 Wister rats were randomly separated into five groups:blank control group,model group,FXT groups of high,middle and low dosage,The rat model of corpulmonale was established by injecting 2% monocrotaline(60 mg/kg)i.p.At the same time,model group,FXT groups of high,middle and low dosage were separately administrated with physical saline or FXT for 21 days.NO,ET-1 and expression of VEGF in bronchi arterioles was measured.Lung tissue sections were examined to study the morphological alternations.Results:FXT could evidently improve the NO content of rat model of CPHD;reduce the ET-1 content;reduce the expression of VEGF in bronchi arterioles.Conclusions:FXT treatment is effective on rat model of CPHD.