| 肺癌组织中FHIT和TPX2基因的表达及临床意义的研究 |
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| 引用本文： | 杨上英,曹颖平,王梅华,康明强,朱婵虹.肺癌组织中FHIT和TPX2基因的表达及临床意义的研究[J].检验医学与临床,2009,6(9):641-643. |
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| 作者姓名： | 杨上英 曹颖平 王梅华 康明强 朱婵虹 |
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| 作者单位： | 福建医科大学附属协和医院检验科,福州,350001 |
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| 摘 要： | 目的探讨FHIT和TPX2基因在肺癌中的表达与临床病理因素的关系。方法采用实时荧光定量聚合酶链反应（RT-PCR）法，检测FHIT和TPX2基因在肺癌组织和癌旁正常肺组织中的表达。结果FHIT基因的表达水平在肺癌组织中的水平比正常肺组织低，差异有统计学意义（P〈0．05），失表达率达74．2％。TPX2基因的表达水平在肺癌组织中的水平比正常肺组织高，差异有统计学意义（P〈0．05），高表达率达64．5％。FHIT的表达异常与吸烟存在相关（P〈0．05），TPX2的表达异常与临床病理因素均无关，两者之间比较差异无统计学意义（P〉0．05）。结论FHIT基因的失表达和TPX2基因的过表达在肺癌的发生发展中起重要作用，吸烟可能导致FHIT基因表达下降诱发肺癌。
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| 关 键 词： | 肺癌 FHIT基因 TPX2基因 实时荧光定量聚合酶链反应 吸烟 |
Expression and clinical significance of FHIT gene and TPX2 gene in lung cancer |
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| YANG Shang-ying,CAO Ying-ping,WANG Mei-hua,KANG Ming-qiang,ZHU Chan-hong.Expression and clinical significance of FHIT gene and TPX2 gene in lung cancer[J].Laboratory Medicine and Clinic,2009,6(9):641-643. |
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| Authors: | YANG Shang-ying CAO Ying-ping WANG Mei-hua KANG Ming-qiang ZHU Chan-hong |
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| Institution: | YANG Shang-ying,CAO Ying-ping,WANG Mei-hua,KANG Ming-qiang,ZHU Chan-hong.Affiliated Union Hospital of Fujian Medical University,Fuzhou 350001,China |
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| Abstract: | Objective To investigate the expression of FHIT gene and TPX2 gene in lung cancer and their relationships with clinicopathological factors.Methods RT-PCR was used to detect the expression of FHIT gene and TPX2 gene in lung cancer tissue and normal control lung tissue.Results The expression level of FHIT gene was significantly lower in lung cancer tissue than in normal control lung tissue,the deletion rate of FHIT gene expression was 74.2%(P<0.05).The expression level of TPX2 gene was significantly higher in... |
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| Keywords: | lung cancer FHIT gene TPX2 gene RT-PCR smoking |
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