| 度洛西汀与帕罗西汀治疗不同症状抑郁症的比较研究 |
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| 引用本文： | 魏昆岭,成玉敏,桑文华,刘增龙. 度洛西汀与帕罗西汀治疗不同症状抑郁症的比较研究[J]. 中国临床药理学杂志, 2011, 27(4) |
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| 作者姓名： | 魏昆岭 成玉敏 桑文华 刘增龙 |
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| 作者单位： | 河北省精神卫生中心,河北保定,071000 |
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| 摘 要： | 目的 比较度洛西汀与帕罗西汀治疗不同症状抑郁症的疗效.方法 将126例符合ICD-10抑郁症诊断标准的患者,按不同主诉(精神症状或躯体症状)分为2组,每组再随机分为2个亚组,分别采用度洛西汀(每天60 mg)和帕罗西汀(每天20 mg)治疗6周,用汉密尔顿抑郁量表(HAMD)评定疗效,用副反应量表(TESS)评定药物不良反应.结果 在以精神症状为主的患者中,度洛西汀组与帕罗西汀组的有效率分别为84%和75%,两者比较差异无显著性(P>0.05);在以躯体症状为主的患者中,度洛西汀组与帕罗西汀组的有效率分别为80%和55%,两者比较差异有显著性(P<0.05).结论 与帕罗西汀相比,度洛西汀治疗伴有躯体症状的抑郁症患者疗效更好.
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| 关 键 词： | 度洛西汀 帕罗西汀 抑郁症 |
Comparative study of duloxetine and paroxitine in the treatment of depression with different symptoms |
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| WEI Kun-ling,CHENG Yu-min,SANG Wen-hua,LIU Zeng-long. Comparative study of duloxetine and paroxitine in the treatment of depression with different symptoms[J]. The Chinese Journal of Clinical Pharmacology, 2011, 27(4) |
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| Authors: | WEI Kun-ling CHENG Yu-min SANG Wen-hua LIU Zeng-long |
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| Affiliation: | WEI Kun-ling,CHENG Yu-min,SANG Wen-hua,LIU Zeng-long(Hebei Mental Health Center,Baoding 071000,Hebei Province,China) |
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| Abstract: | Objective To compare efficacy of duloxetine and paroxitine in the treatment of depression with different symptoms.Methods A total of 126 patients who met the criteria of ICD-10 for depression were assigned to two groups based on different complaints(mental or somatic complaints).Every group was randomly divided into two subgroups treated with duloxetine 60 mg per day or paroxitine 20 mg per day for 6 weeks.The efficacy was assessed by Hamilton depression scale(HAMD),and the safety was assessed by treatment ... |
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| Keywords: | duloxetine paroxitine depression |
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