Efficacy of Nitazoxanide against Clinical Isolates of Mycobacterium tuberculosis |
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| Authors: | Kristina Shigyo Oksana Ocheretina Yves Mary Merveille Warren D. Johnson Jean William Pape Carl F. Nathan Daniel W. Fitzgerald |
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| Affiliation: | Center for Global Health, Department of Medicinea;Department of Microbiology and Immunology,b Weill Cornell Medical College, New York, New York, USA;GHESKIO Centres, Port-au-Prince, Haitic |
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| Abstract: | Nitazoxanide (NTZ) has bactericidal activity against the H37Rv laboratory strain of Mycobacterium tuberculosis with a MIC of 16 μg/ml. However, its efficacy against clinical isolates of M. tuberculosis has not been determined. We found that NTZ''s MIC against 50 clinical isolates ranged from 12 to 28 μg/ml with a median of 16 μg/ml and was unaffected by resistance to first- or second-line antituberculosis drugs or a diversity of spoligotypes. |
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