| rhBMP-2/PLA复合涂层种植体骨内诱导成骨的实验研究 |
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| 引用本文： | 程祥荣,杜兵,韩光丽.rhBMP-2/PLA复合涂层种植体骨内诱导成骨的实验研究[J].口腔医学研究,2002,18(5):295-296. |
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| 作者姓名： | 程祥荣 杜兵 韩光丽 |
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| 作者单位： | 武汉大学口腔医学院,湖北,武汉,430079 |
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| 摘 要： | 目的：观察基因重组人骨形成蛋白-（recombinanthuman bone morphogenetic protein-2，rhBMP-2）和聚乳酸（polylactic acid，PLA）复合形成的活性涂层种植体骨内诱导成骨活性。方法：将rhBMP-2与聚乳酸复合构建活性涂层种植体，植入兔股骨内，分别于4，8，12，16周处死动物，进行组织学及扫描电镜及组织化学观察，检测其成骨活性。结果：构建的活性涂层种植体具有骨诱导能力，PLA为rhBMP-2的良好控释载体。结论：rhBMP-2/PLA涂层具有良好的生物相容性和骨诱导活性，是一种理想的种植体形式。
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| 关 键 词： | 复合涂层种植体 基因重组人内形成蛋白－2 聚乳酸 控释骨架 成骨活性 PLA rhBMP－2 |
| 文章编号： | 1671-7651(2002)05-0295-02 |
| 修稿时间： | 2002年7月4日 |
Experimental Research of Osteoinductive Activity of rhBMP-2/PLA Composite as a New Kind of Implant Coating Material |
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| CHENG Xiang-rong,DU Bing,HAN Guang-li.Stomatological college and hospital of wuhan University,Wuhan.Experimental Research of Osteoinductive Activity of rhBMP-2/PLA Composite as a New Kind of Implant Coating Material[J].Journal of Oral Science Research,2002,18(5):295-296. |
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| Authors: | CHENG Xiang-rong DU Bing HAN Guang-liStomatological college and hospital of wuhan University Wuhan |
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| Institution: | CHENG Xiang-rong,DU Bing,HAN Guang-li.Stomatological college and hospital of wuhan University,Wuhan 430079 |
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| Abstract: | Objective:To study the osteoinductive activity of rhBMP-2/PLA coated implants.Methods:rhBMP-2/PLA coated implants were implanted into the bone of rabbits.After 4,8,12,16weeks,osteoinductive activity of rhBMP-2 was examined by histology and SEM observation.Results:rhBMP-2/PLA coated implant has the osteoinductive activity.PLA could be used as a good carrier and control the delivery of rhBMP-2.Conclusions:rhBMP-2/PLA coating posses definitive biocompatibility and osteoinductivity ,and may be an ideal type of implant coating . |
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| Keywords: | rhBMP-2 PLA Controlled release carrier Osteoinductive activity |
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