Sexually Dimorphic Expression of Reelin in the Brain of a Mouse Model of Alzheimer Disease |
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| Authors: | Giampiero Palladino Vincenzina Nicolia Gabor G. Kovacs Sonia Canterini Viviana Ciraci Andrea Fuso Franco Mangia Sigfrido Scarpa Maria Teresa Fiorenza |
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| Affiliation: | 1.Department of Psychology, Section of Neuroscience and “Daniel Bovet” Neurobiology Research Center,Sapienza University of Rome,Rome,Italy;2.Department of Surgery “P. Valdoni”,Sapienza University of Rome,Rome,Italy;3.Institute of Neurology Medical University of Vienna,Vienna,Austria;4.European Center for Brain Research (CERC)/IRCCS Santa Lucia Foundation,Rome,Italy |
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| Abstract: | ![]()
Recent evidence highlights the protective role of reelin against amyloid β (Aβ)-induced synaptic dysfunction and cognitive impairment in Alzheimer disease (AD). In this study, exploiting TgCRND8 mice that overexpress a mutant form of amyloid β precursor protein (AβPP) and display an early onset of AD neuropathological signs, we addressed the question whether changes of reelin expression eventually precede the appearance of Aβ-plaques in a sex-dependent manner. We show that sex-associated and brain region-specific differences in reelin expression appear long before Aβ-plaque formation. However, in spite of a downregulation of reelin expression compared to males, TgCRND8 females display fewer Aβ-plaques, suggesting that additional factors, other than sex and reelin level, influence amyloidosis in this mouse model. |
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