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Prognostic impact of PD-1 and its ligands in renal cell carcinoma |
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| Authors: | Franziska Erlmeier Wilko Weichert Andres Jan Schrader Michael Autenrieth Arndt Hartmann Sandra Steffens Philipp Ivanyi |
| Institution: | 1.Institute for Pathology and Pathological Anatomy,Technische Universit?t München,Munich,Germany;2.Member of the German Renal Cell Tumor Consortium,Jena,Germany;3.Member of the German Cancer Consortium (DKTK),Heidelberg,Germany;4.Clinic for Urology,University Hospital Muenster,Muenster,Germany;5.Department of Urology,Technical University of Munich, Klinikum rechts der Isar,Munich,Germany;6.Institute of Pathology,University Hospital of Erlangen,Erlangen,Germany;7.Department of Hematology, Hemostasis, Oncology and Stem Cell Transplantation,Hannover Medical School,Hannover,Germany |
| Abstract: | Programmed death-1 receptor (PD-1) and programmed death-1 receptor-ligand (PD-L1) have been suggested to play a role as prognostic markers in clear cell renal cell carcinoma (ccRCC). The association between PD-L1 and prognosis seems to be more robust than for PD-1. Further, preliminary analyses suggest that neither PD-1 nor its ligands play a role as prognostic markers in non-clear cell RCC, while the prognostic role of PD-L2 in ccRCC as well as in non-clear cell RCC remains unclear. |
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