| 重组GnRH主动免疫对公猪体重及生长激素和IGF-I的影响 |
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| 引用本文： | 方富贵,张运海,刘亚,苏时萍,蒲勇,李运生,陶勇,章孝荣. 重组GnRH主动免疫对公猪体重及生长激素和IGF-I的影响[J]. 中国免疫学杂志, 2011, 27(9): 809-813. DOI: 10.3969/j.issn.1000-484X.2011.09.011 |
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| 作者姓名： | 方富贵 张运海 刘亚 苏时萍 蒲勇 李运生 陶勇 章孝荣 |
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| 作者单位： | 安徽农业大学动物科技学院,合肥,230036 |
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| 基金项目： | 安徽省教育厅自然科研重点项目 |
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| 摘 要： | 目的:探讨重组GnRH六聚体-麦芽糖结合蛋白(MBP-GnRH-6)主动免疫对公猪体重、生长激素和胰岛素样生长因子-I的影响。方法:7头公猪在9周龄时用重组GnRH主动免疫,17周龄时加强免疫,免疫和屠宰前1天称猪体重,酶联免疫分析法检测血清猪生长激素,放射免疫分析法检测血清IGF-I和睾酮水平,Pearson相关分析血清睾酮与IGF-I的相关性。结果:MBP-GnRH-6主动免疫猪血清睾酮浓度显著地低于阳性对照组(P<0.05),体重显著重于阴性对照组(P<0.05),但不影响公猪血清生长激素水平(P>0.05)。在17~21周龄时,免疫组公猪血清IGF-I浓度显著低于阳性对照组(P<0.05),21~25周龄时免疫组公猪血清IGF-I显著高于阴性对照组(P<0.05)。相关分析表明血清睾酮与IGF-I呈正相关。结论:MBP-GnRH-6主动免疫改变了公猪生长性能,增加体重,其作用途径可能是睾酮通过调控血清IGF-I水平来调控的。
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| 关 键 词： | 重组GnRH 公猪 体重 生长激素 IGF-I |
Effects of body weight,growth hormone and IGF-I of active immunization against recombinant GnRH in boars |
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| FANG Fu-Gui,ZHANG Yun-Hai,LIU Ya,SU Shi-Ping,PU Yong,LI Yun-Sheng,TAO Yong,ZHANG Xiao-Rong. Effects of body weight,growth hormone and IGF-I of active immunization against recombinant GnRH in boars[J]. Chinese Journal of Immunology, 2011, 27(9): 809-813. DOI: 10.3969/j.issn.1000-484X.2011.09.011 |
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| Authors: | FANG Fu-Gui ZHANG Yun-Hai LIU Ya SU Shi-Ping PU Yong LI Yun-Sheng TAO Yong ZHANG Xiao-Rong |
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| Affiliation: | FANG Fu-Gui,ZHANG Yun-Hai,LIU Ya,SU Shi-Ping,PU Yong,LI Yun-Sheng,TAO Yong,ZHANG Xiao-Rong.College of Animal Science and Technology,Anhui Agricultural University,Hefei 230036,China |
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| Abstract: | Objective:To explore effects of body weight,growth hormone and insulin-like growth factor-I,IGF-I of active immunization against recombinant gonadotropin releasing hormone(MBP-GnRH-6) in boars.Methods:Seven boars at 9 weeks were actively immunized against MBP-GnRH-6,and the booster immunization was administered at 17 weeks.The body weights were measured at 1 d before immunization and slaughter,respectively.The concentrations of pGH,IGF-I and testosterone(T) in serum were determined by enzyme-linked immunoso... |
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| Keywords: | IGF-I |
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