均匀设计法优选祛斑凝胶剂基质处方

目的：优选祛斑凝胶剂基质处方。方法：采用U₆（6²×3）均匀设计法，以凝胶剂的流变学参数（在室温下的黏度和屈服值、在体表温度下的黏度和屈服值、触变性）为指标，优化凝胶剂成型处方。结果：祛斑凝胶剂基质最佳处方为卡波姆9 401.0 g，甘油5 mL，pH 5~6。结论：通过建立凝胶基质质量与凝胶流体学参数回归模型，能直接反应各因素影响作用，为凝胶基质处方的筛选能提供一定的参考依据，采用该方法制备的祛斑凝胶剂均匀细腻，黏度适中，触变性良好。

Optimization of formulas of Quban gel by uniform design

Objective: To optimize formulas of Quban gel. Method: The U₆ (6²×3) uniform design was adopted to optimize gel formulas, with rheological parameters, such as viscosity and yield value in room temperature, viscosity and yield value in average temperature of skin, thixlotropy. Result: The optimum proportion of matrix was made of 1.0 g carbomer 940, 5 mL glycerin and pH value 5-6. Conclusion: The regression model for gel matrix quality and gel rheological parameters was established to directly reflect the impacting effect of various factors, and provide certain preference basis for the screening of gel matrix formulas. Quban gel prepared by the method was evenly distributed, moderately viscous and highly thixotropic.