| 脊髓缺血再灌注损伤中神经细胞凋亡的研究 |
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| 引用本文： | 朱庆三,尹飞,郭丽,杨晓钰,刘景臣. 脊髓缺血再灌注损伤中神经细胞凋亡的研究[J]. 吉林大学学报(医学版), 2003, 29(5): 609-610 |
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| 作者姓名： | 朱庆三 尹飞 郭丽 杨晓钰 刘景臣 |
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| 作者单位： | 吉林大学中日联谊医院骨科,吉林长春130031;吉林大学公共卫生学院毒理学教研室 |
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| 基金项目： | 吉林省科技厅科研项目;990563-1; |
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| 摘 要： | 目的 :探讨脊髓缺血再灌注损伤后细胞死亡方式。方法 :制作脊髓缺血再灌注损伤模型后 ,采用电镜和荧光染色方法检测脊髓神经细胞的死亡方式。结果 :电镜观察发现脊髓缺血再灌注损伤 4h后各个时间点均可检测到凋亡细胞。在荧光显微镜下缺血再灌注 4h后各时间点均可见到凋亡及坏死的神经细胞 ,其中以凋亡细胞为主 ,再灌注 2 4 h最多。结论 :脊髓缺血再灌注损伤后细胞死亡以凋亡为主
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| 关 键 词： | 脊髓 缺血再灌注损伤 细胞凋亡 |
| 文章编号： | 1671-587X(2003)05-0609-02 |
| 修稿时间： | 2022-09-05 |
Study on Neuron Apoptosis in Spinal Cord Ischemical Reperfusion Injury |
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| ZHU Qing san ,YIN Fei ,GUO Li ,YANG Xiao yu ,LIU Jing chen. Study on Neuron Apoptosis in Spinal Cord Ischemical Reperfusion Injury[J]. Journal of Jilin University: Med Ed, 2003, 29(5): 609-610 |
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| Authors: | ZHU Qing san YIN Fei GUO Li YANG Xiao yu LIU Jing chen |
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| Affiliation: | ZHU Qing san 1,YIN Fei 1,GUO Li 2,YANG Xiao yu 1,LIU Jing chen 1 |
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| Abstract: | Objective: To explore the death pattern of rat spinal nerve cells after I/R injury. Methods: After the rat model of ischemical reperfusion (I/R) injury was set up, the death pattern of rat meirpms was detected under the electron microscopy and fluorescence staining. Results:The apoptosis cells were observed in the experimental groups which were reperfused over 4 h after I/R injury under electron microscope. Both the apoptosis cells and necrosis cells were observed in the experimental groups which were reperfused over 4 h after I/R injury under fluorescence microscope, but the most death cells were apoptosis cells, and the apoptosis cells reached peak at 24 h after reperfusion. Conclusion: Apoptosis is the main death pattern in spinal cord I/R injury. [ |
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| Keywords: | Spinal cord Ischemical reperfusion injury Apoptosis |
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