急性心肌梗塞血清可溶性细胞间粘附分子的变化及意义

目的 探讨急性心肌梗塞(AMI)血清可溶性细胞间粘附分子(SICM-1)的变化及临床意义.方法 采用ELISA法测定了30例AMI患者血清SICAM-1,并与30例不稳定心绞痛(UAP)和30例正常人进行比较.结果AMI发生后24小时内血清sICAM-1明显高于UAP和正常对照组(P<0.001),梗塞面积越大,sICAM—1升高越明显.AMI发生后7日内,sICAM—1呈上升趋势,7～14天sICAM-1开始下降,14天仍高于其余两组.结论 血清sICAM-1与AMI发生及梗塞面积呈正相关,可作为AMI病情变化的观察指标之一.

Change of serum soluble intercelluler adhesion molecule - 1 in patients with acute myocardial infarction

[Abstract] Objective To investigate the change of serum soluble intercelluler adhesion molecule - 1 in patients with acute myocardial infarction (AMI) and its significance. Methods The level of serum sICAM - 1 was determinated with enzyme-linked immunosorbent assay (ELISA) in 30 patients with AMI, 30 patients with unstable angina pectoris(UAP), and 30 normal controls. Results The serum level of sICAM - 1 in patients with AMI 24 hours within the onset was higher than that in the other two groups(P < 0.001). The larger the infarction area, the higher the level of sICAM - 1 in patients with AMI was found. The level of sICAM - 1 in patients with AMI increased from the onset to 7 days and decreased from 7 to 14 days, but was still higher than that in the other two groups(P <0.001) even on 14th day. Conclusion The level of serum sICAM - 1 is positively related to the development and the area of AMI, and may be used as a marker to monitor the change of AMI.