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| 姜黄素对D-半乳糖所致衰老小鼠学习记忆的影响 | |
| 引用本文： | 张晶莹,高峰,张琨,邹梅. 姜黄素对D-半乳糖所致衰老小鼠学习记忆的影响[J]. 职业与健康, 2011, 27(9): 995-997 |
| 作者姓名： | 张晶莹 高峰 张琨 邹梅 |
| 作者单位： | 吉林省卫生监测检验中心毒理所,长春市,130062 |
| 基金项目： | 吉林省卫生厅重点实验室资助项目 |
| 摘 要： | 目的观察姜黄素对D半-乳糖所致衰老小鼠学习记忆障碍的保护作用。方法 50只ICR小鼠,随机分为5组:对照组,阿尔茨海默病(AD)模型组,姜黄素预处理组、同时处理组和后处理组。采用跳台试验和避暗试验方法,观察姜黄素对AD模型小鼠学习记忆障碍的影响。结果行为学试验显示,模型组小鼠潜伏期短,错误次数增多,与对照组比,P<0.05;姜黄素预处理组和同时处理组潜伏期延长,错误次数减少,学习记忆明显改善,与模型组比,P<0.05。结论姜黄素对AD模型小鼠的学习记忆能力减退具有改善作用。 |
| 关 键 词： | 姜黄素 D半-乳糖 学习记忆 |
Effect of Curcumin on Learning and Memory of Aging Mice Caused by D-galactose |
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| ZHANG Jing-ying,GAO Feng,ZHANG Kun,ZOU Mei. Effect of Curcumin on Learning and Memory of Aging Mice Caused by D-galactose[J]. Occupation and Health, 2011, 27(9): 995-997 | |
| Authors: | ZHANG Jing-ying GAO Feng ZHANG Kun ZOU Mei |
| Affiliation: | ZHANG Jing-ying,GAO Feng,ZHANG Kun,ZOU Mei(Jilin Health Monitoring and Inspection Center,Jilin,130062,China) |
| Abstract: | [Objective]To observe the sheltering effect of curcumin on learning and memory impairment of aging mice caused by D-galactose.[Methods]A total of 50 ICR mice were randomly divided into 5 groups: control group,Alzheimer's disease(AD) model group,curcumin pre-treatment group,co-treatment group,post-treatment group.Step down test and step-through test were used to observe the effect of curcumin on learning and memory impairment by D-galactose in mice.[Results]Ethology test showed that the latency period of AD ... |
| Keywords: | curcumin D-galactose Learning and memory |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |