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| PARP-1基因Val762Ala多态性与乳腺癌易感性的关系 | |
| 引用本文： | 王昆鹏,杨淋清,刘建军,庄志雄,任泽舫. PARP-1基因Val762Ala多态性与乳腺癌易感性的关系[J]. 职业与健康, 2011, 27(19): 2165-2167 |
| 作者姓名： | 王昆鹏 杨淋清 刘建军 庄志雄 任泽舫 |
| 作者单位： | 1. 中山大学公共卫生学院,广东省广州市510080;深圳市疾病预防控制中心 2. 深圳市疾病预防控制中心 3. 中山大学公共卫生学院,广东省广州市,510080 |
| 基金项目： | 国家自然科学基金资助项目 |
| 摘 要： | 目的探讨DNA修复基因聚腺苷二磷酸核糖聚合酶-1(PARP-1)单核苷酸多态性位点Val762Ala基因多态性与中国人群乳腺癌易感性的关系。方法采用Sequenom MassARRAY单核苷酸多态性(SNP)基因型分析技术对经病理确诊的原发性乳腺癌女性患者837例(病例组)和健康对照组865例进行PARP-1基因单核苷酸位点Val762Ala基因分型。以非条件logistic回归计算优势比(odds ratio,OR)及其95%可信区间(CI)评价各基因型与乳腺癌发病风险的关系。数据均由SPSS13.0统计软件分析。结果病例组和对照组中TT、TC、CC和TC+CC 4种基因型的分布分别差异无统计学意义,OR[95%CI]值分别为1、1.07(0.83～1.39)、1.03(0.70～1.36)、1.08(0.82～1.33)。结论 Val762Ala基因型与乳腺癌易感性无显著相关性。PARP-1基因Val762Ala多态性在乳腺癌发病过程中无作用。 |
| 关 键 词： | 乳腺癌 聚腺苷二磷酸核糖聚合酶-1 单核苷酸多态性 |
Relation between PARP-1 Val762Ala Polymorphisms and Susceptibility to Breast Cancer |
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| WANG Kun-peng,YANG Lin-qing,LIU Jian-jun,ZHUANG Zhi-xiong,REN Ze-fang. Relation between PARP-1 Val762Ala Polymorphisms and Susceptibility to Breast Cancer[J]. Occupation and Health, 2011, 27(19): 2165-2167 | |
| Authors: | WANG Kun-peng YANG Lin-qing LIU Jian-jun ZHUANG Zhi-xiong REN Ze-fang |
| Affiliation: | WANG Kun-peng,YANG Lin-qing,LIU Jian-jun,ZHUANG Zhi-xiong,REN Ze-fang,(School of Public Health,Zhongshan University,Guangzhou 510080,China) |
| Abstract: | [Objective] To investigate the association between the Val762Ala polymorphisms of the poly(ADP-ribose) polymerase-1(PARP-1) gene and susceptibility to breast cancer in a Chinese population. [Methods]PARP-1 Val762Ala genotyping were conducted in 837 breast carcinoma patients and 865 cancer-free controls by Sequenom MassARRAY(SNP) genotype analysis technique.The associations between genotypes and breast cancer risk were estimated by computing the ORs and their 95% CIs from non-conditional logistic regression ... |
| Keywords: | Breast cancer Poly(ADP-ribose) polymerase-1 Single nucleotide polymorphisms |
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