cTnI、MB和CK-MB联合检测在急性心肌梗死诊断中的临床应用

目的探讨心肌肌钙蛋白I（cTnl）、肌红蛋白（MB）和肌酸激酶同工酶（CK-MB）对急性心肌梗死（AMI）诊断的临床价值。方法对136例AMI患者于胸痛发作后24 h内检测血清中cTnI、MB和CK-MB水平,比较这3项指标对AMI诊断的敏感性和特异性。结果急性AMI患者的cTnI、MB、CK-MB检测结果分别为（1.29±0.93）、（426±214）、（23.7±17.8）μg/L,较正常对照组均有显著性升高（P〈0.05）。cTnl、MB、CK-MB对AMI的敏感性分别为97.1%、98.5%和77.9%,特异性分别为97.7%、87.8%和95.0%。结论急性AMI患者的cTnI、MB、CK-MB的值均明显升高。3项指标在AMI诊断中具有较高的灵敏度和特异性,其中以cTnI最佳。3项指标联合检测效果更好,在AMI的诊断中起到重要作用。

Clinical Application of Joint Detection of cTnI, MB and CK-MB in the Diagnosis of Acute Myocardial Infarction

[Objective]To explore the clinical significance of cTnI,MB and CK-MB in the diagnosis of acute myocardial infarction（AMI）. [Methods]The levels of cTnI,MB and CK-MB of 136 AMI patients were detected within 24 hours after chest pain.The sensitivity and specificity of three indexes in the diagnosis of AMI were compared. [Results]The level of cTnI,MB and CK-MB of AMI patients was（1.29±0.93） μg/L,（426 ±214） μg/L and（23.7±17.8） μg/L respectively,which was significantly higher than that of the normal controls（P0.05）.The sensitivity of cTnI,MB and CK-MB was 97.1%,98.5% and 77.9% respectively.The specificity of cTnI,MB and CK-MB was 97.7%,87.8% and 95.0% respectively. [Conclusion]The serum concentrations of cTnI,MB and CK-MB increased significantly in AMI patients.Three indexes have high sensitivity and specificity in the diagnosis of AMI,and cTnI is the best index.Joint detection of cTnI,MB and CK-MB has better effect,which play an importance role in the diagnosis of AMI.