Nucleocytoplasmic Shuttling of Influenza A Virus Proteins |
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| Authors: | Jing Li Meng Yu Weinan Zheng Wenjun Liu |
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| Affiliation: | 1.Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China; E-Mails: (J.L.); (M.Y.); (W.Z.);2.University of Chinese Academy of Sciences, Beijing 100049, China |
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| Abstract: | Influenza viruses transcribe and replicate their genomes in the nuclei of infected host cells. The viral ribonucleoprotein (vRNP) complex of influenza virus is the essential genetic unit of the virus. The viral proteins play important roles in multiple processes, including virus structural maintenance, mediating nucleocytoplasmic shuttling of the vRNP complex, virus particle assembly, and budding. Nucleocytoplasmic shuttling of viral proteins occurs throughout the entire virus life cycle. This review mainly focuses on matrix protein (M1), nucleoprotein (NP), nonstructural protein (NS1), and nuclear export protein (NEP), summarizing the mechanisms of their nucleocytoplasmic shuttling and the regulation of virus replication through their phosphorylation to further understand the regulation of nucleocytoplasmic shuttling in host adaptation of the viruses. |
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| Keywords: | influenza A virus nucleocytoplasmic shuttling virus replication |
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