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| 环氧合酶-2与卵巢肿瘤研究进展 | |
| 引用本文： | 祝英杰（综述）,冯玉昆（审校）,董菊颖（审校）. 环氧合酶-2与卵巢肿瘤研究进展[J]. 世界肿瘤杂志, 2008, 7(1): 68-70 |
| 作者姓名： | 祝英杰（综述） 冯玉昆（审校） 董菊颖（审校） |
| 作者单位： | 云南省肿瘤医院,妇瘤科,云南,昆明,650118;云南省肿瘤医院,妇瘤科,云南,昆明,650118;云南省肿瘤医院,妇瘤科,云南,昆明,650118 |
| 摘 要： | 环氧合酶-2在正常生理状态下多数组织内检测不到，而在组织受到炎症、缺氧等刺激时由炎性细胞生成。COX-2参与多种病理生理过程，包括急慢性炎症、疼痛和肿瘤等。近来在多种恶性肿瘤中发现有COX-2的表达上调，现综述COX-2蛋白表达与卵巢上皮癌的发生发展的相关性及其可能机制。 |
| 关 键 词： | 卵巢肿瘤 前列腺素过氧化物合酶 |
Advance in Cyclooxygenase-2 expression and ovarian tumors |
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| Affiliation: | ZHU Yin-jie, FENG Yu-kun, DONG Ju-yin (Department of gynecologic tumour, Yunnan Province Cancer Hospital, Kunming, Yunnan 650118 China) |
| Abstract: | Cyclooxygenase-2 （COX-2） in most tissues is not detected in normal physiological states, and it is produced by inflammatory cells due to the inflammation and hypoxia. COX-2 takes part in many pathological and physiological courses including acute and chronic inflammation, pain and tumor. The COX-2 expression in many malignant tumors was up-regulated. This review describes the COX-2 overexpression may related to the processes of malignant transformation and development of human ovarian carcinomas. |
| Keywords: | Ovarian carcinoma cyclooxygenase-2 |
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