神经肽Y在肾移植围手术期与血压的关系

目的终末期尿毒症患者血浆神经肽Y（NPY）异常升高,与血压的变化呈正相关。本研究探讨血浆NPY水平在成功肾移植围手术期的临床意义及其与患者血压的关系。方法采集116例终末期尿毒症患者手术前、术后24h、出院前1d外周静脉血标本5ml,测定血浆NPY和肌酐（Cr）水平,同时测量记录平均动脉压。对照组为20例健康志愿者。结果在成功肾移植手术后出院前1d,血Cr水平恢复正常,血浆NPY水平有明显降低,与手术前比较,有显著性差异（P〈0．05）;但又明显高于健康志愿者血浆NPY平均值,比较有显著性差异（P〈0．05）;手术后患者平均动脉压无明显降低,个别反而较手术前更高,与手术后血浆NPY水平的变化无相关性。结论终末期尿毒症患者成功接受肾移植后,在出院前1d,肾功能恢复正常情况下其血浆NPY水平明显下降,但与患者的平均动脉压无相关性。

The relationship between plasma concentration of neuropeptide Y in successful renal transplantation perioperative period and blood pressure

Objectives The aim of the present study was to assess the relationship between plasma concentration of neuropeptide Y(NPY)in successful renal transplantation perioperative period and blood pressure.Methods A total of 116 patients with chronic renal failure were examined after successful kidney transplantation.In kidney transplant recipients,plasma concentration of NPY and creatinine(Cr)were assessed immediately before kidney transplantation and additional two times were examined at 24 hours after successful...